The usage of plants, plant extracts or plant-derived pure chemicals to treat disease become a therapeutic modality, which has stood the test of time. Today several pharmacological classes of drugs include a natural product prototype. Aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine are a few examples of modern drugs, which were originally discovered through the study of traditional cures and folk knowledge of indigenous people. A team work amongst ethnobotanists, ethnopharmacologists, physicians and phytochemists is must for the fruitful outcome on medicinal plants research. While the ethnopharmacologists have a greater role in the rationalization of combination of activities, the phytochemists role will slightly shift towards standardization of herbal medicines.