Abstract: Dalbergia spinosa Roxb. (Family: Fabaceae) has many
traditional uses in Bangladesh. The crude methanol extract of the stem barks
of D. spinosa Roxb. was investigated for possible antinociceptive activity
using acetic acid induced writhing model in mice. Phytochemical analysis was
also performed using standard procedures to detect the presence of phytochemicals
in the crude plant extract. The study results showed 37.20% inhibition of writhings
in the tested mice when methanol extracts were given intraperitoneally (i.p.)
at the dose of 250 mg extract kg-1 b.wt. The maximum inhibition (40.01%)
of nociception effect was achieved at 500 mg extract kg-1 b.wt.,
i.p. which was also compared with the antinociceptive activity of the standard
drug, diclofenac sodium at the dose of 25 mg extract kg-1 b.wt. which
produced 68.37% inhibition of nociception effect. The inhibition of writhings
was calculated in respective to control group and it was found that p-values
(<0.0001) calculated by student’s t-test were statistically significant.
However, the phytochemical screening revealed the presence of alkaloid, steroid,
flavonoid, tannin, reducing sugar and gum. Finally, it can be concluded that
crude methanol extracts of D. spinosa stem barks contain biologically
active phytoconstituents exhibiting significant dose-dependent antinociceptive
activity in the mice model used. Thus, it is recommended to isolate and characterize
the compounds for the development of new analgesics.
S.Z. Raihan, M.M. Monir, P. Biswas, S.K. Biswas, A. Chowdhury, J. Das and A.C. Das, 2012. Antinociceptive Activity of Dalbergia spinosa Roxb. Stem Barks. Journal of Biological Sciences, 12: 202-205.
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