The main objective of this review is to provide advance information for the drug discovery research from rare medicinal plant Kalanchoe pinnata, which has potential anticancer and insecticidal compounds etc. This plant leaf and stem and leaf portions contains significant chemicals which are most needed in medicinal industry, e.g., Bufadienolides. It is potential anticancer and insecticidal active compound. The other phytochemicals proved against UTI, parasitic, bacterial infections, antiulcer active and antidepressant. Now it becomes endangered plant which needs to be conserved as well as explored for its significant green chemistry.