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Articles by A. Aida Azlina
Total Records ( 2 ) for A. Aida Azlina
  A. Aida Azlina , H.S. Farihah , H.M.S. Qodriyah and M.F. Nur Azlina
  The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) convert inactive circulating 11-keto steroids into active glucocorticoids, amplifying local glucocorticoid action. It is elevated in adipose tissue in obese humans and rodents, suggesting that adipose tissue glucocorticoid excess may be the causative factor for obesity. This study was conducted to evaluate the effects of Piper sarmentosum (PS) water extract and glycyrrhizic acid (GCA) on 11β-HSD1 bioactivity in ovariectomized induced obese rats. Fourty-two female Sprague-Dawley rats were randomly divided into six groups; four treatments (PS, GCA, CTRL and SHM) and two basal (B-CTRL and B-SHM). All groups underwent ovariectomy excluding SHM and B-SHM which underwent sham operation. Basal groups were sacrificed on the first day of treatment, while ovariectomized groups were given PS extract (0.125 g kg-1), GCA (0.120 g kg-1) and water (CTRL), respectively, while SHM received only water. Blood pressure was measured monthly while body weight weekly. After five months, rats were sacrificed and liver, heart and visceral adipose tissues were taken for analysis. Piper sarmentosum (PS) and GCA group showed a significant reduction in enzyme activity but no difference in body weight compared to CTRL group. Meanwhile only the blood pressure in GCA group was significantly higher after three months of treatment as compared to CTRL group but no difference after five months. In conclusion, both PS water extract and GCA have the ability to reduce 11β-HSD1 enzyme activity but only GCA cause an increased in blood pressure.
  A. Aida Azlina , S. Farihah , M.S. Qodriyah and M.F. Nur Azlina
  This study was conducted to evaluate the effects of Piper sarmentosum (PS) extract and glycyrrhizic acid (GCA) on plasma adiponectin and blood glucose in ovariectomy-induced obese rats. Twenty eight female Sprague-Dawley rats were randomly divided into four groups. Three groups were ovariectomized (OVX), while the remaining group underwent sham operation. The OVX groups were given PS water extract (0.125 g kg-1), GCA (0.120 g kg-1) and water (CTRL), respectively, while the Sham-Operated (SHM) group received only water. Plasma adiponectin and blood glucose were measured at zero, three and five months of treatment, while body weight was measured weekly. All the OVX groups had a significant reduction (p<0.05) in the plasma adiponectin compared to the SHM group. After three and five months of treatment, both PS and GCA treated group showed a significant increment (p<0.05) in the plasma adiponectin level compared to CTRL group. While, the blood glucose level, only PS treated group showed significant reduction (p<0.05) after three and five months of treatment compared to CTRL group but no significant difference (p<0.05) occurred in body weight compared to CTRL group. Our finding suggests that water extract of Piper sarmentosum may have the ability to reduce the amount of visceral fat in the body as shown by the increment of plasma adiponectin and improve blood glucose levels in obese rats.
 
 
 
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