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Articles by L. Pari
Total Records ( 2 ) for L. Pari
  G. Saravanan and L. Pari
  The aim of the present study was to investigate the hypoglycaemic and antihyperglycaemic effect of Syzygium cumini (S. cumini) bark in diabetic rats. Diabetes was induced in male albino Wistar rats by a single intraperitoneal injection of streptozotocin (45 mg kg-1 body weight). An aqueous extract of S. cumini bark (SBEt) was administered orally (75, 150 and 300 mg kg-1 body weight) for 45 days and changes in blood glucose, urine sugar, food and fluid intakes and body weight were examined in diabetic rats. Glibenclamide was used as a standard reference drug. The levels of blood glucose and urine sugar were increased significantly in diabetic rats. Oral administration of SBEt to diabetic rats led to significantly decreased levels of blood glucose and urine sugar. The effect exerted by the extract at a dose of 300 mg kg-1 body weight was greater than that of doses 75 and 150 mg kg-1 body weight. The daily food and fluid intakes were significantly increased while the body weights were significantly reduced in diabetic rats when compared to normal rats. Treatment with SBEt significantly restored the above physiological parameters to near normal in streptozotocin diabetic rats. During oral glucose tolerance test (OGGT), long-term administration of SBEt was able to significantly decrease the blood glucose concentrations at 30, 60, 90 and 120 min when compared to the OGTT pattern of diabetic rats. The effect of SBEt at 300 mg kg-1 body weight was better than glibenclamide (600 µg kg-1 body weight). These results suggest that SBEt possesses a significant antidiabetic effect by attenuating the above biochemical and physiological alterations in streptozotocin diabetes. Further, our findings revealed the possible therapeutic value of S. cumini bark for the better control, management and prevention of diabetes mellitus progression.
  G. Saravanan and L. Pari
  Cogent db, a poly herbal drug, was investigated for its beneficial effect in diabetic rats on derangement in glycoprotein components. Diabetes was induced in male albino Wistar rats by a single intraperitoneal injection of alloxan (150 mg kg-1) and the animals were divided into 5 groups as follows: Group 1: Normal untreated rats, Group 2: Normal rats treated with Cogent db (450 mg kg-1), Group 3: Diabetic control rats, Group 4: Diabetic rats treated with Cogent db (450 mg kg-1) and Group 5: Diabetic rats treated with glibenclamide (600 μg kg-1). The effect of Cogent db on blood glucose, plasma insulin, urine sugar, plasma and tissue glycoproteins studied was in comparison to glibenclamide, a standard reference drug. The levels of blood glucose, urine sugar, plasma glycoproteins were increased significantly whereas the level of plasma insulin was significantly decreased in diabetic rats. There was a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine, fucose in the liver and kidney of diabetic rats. Oral administration of Cogent db to diabetic rats for 45 days significantly decreased levels of blood glucose, urine sugar and plasma glycoproteins. On the other hand, the levels of plasma insulin and tissue sialic acid were increased while the levels of tissue hexose, hexosamine and fucose were near normal. Cogent db was more effective than glibenclamide in restoring the values of these parameters. It is likely that the changes in glycoprotein metabolism induced by hyperglycaemia will have biological and possibly pathological importance in the development of diabetic complications. The present investigation indicates that Cogent db treatment possesses a significant beneficial effect on glycoproteins in addition to its antidiabetic action.
 
 
 
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