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Articles by R. Parmaguru
Total Records ( 1 ) for R. Parmaguru
  Priya Ranjan , Papiya Mitra Mazumder , R. Parmaguru , Dinakar Sasmal , Rakesh Kumar Sinha , Yogender Aggarwal and Joyani Das
  Background and Objective: Salvia species have been used since ancient times for more than 60 different ailments. Salvia splendens shows a wide availability in Jharkh and region. According to existing literature, its hypoglycemic activity has already been established in diabetic-rodent model. Therefore, an effort has been made to further explore the efficacy of the active fraction of the plant against diabetes and diabetic neuropathy. Materials and Methods: The plant material was collected, shade dried and extracted with methanol. Ethyl acetate fraction of the methanolic extract (SSEA) was subjected to various tests for neuropathic pain assessment (Tail flick, Cold allodynia, R and all Selitto), biochemical tests (fasting blood glucose level, lipid peroxidation, reduced glutathione, catalase levels in brain), Motor Nerve Conduction Velocity (MNCV) determination and histopathological evaluation of the sciatic nerve. Results and Conclusion: There was a significant decrease in blood glucose level in animals treated with SSEA. At a dose of 400 mg kg-1, SSEA showed reduction of MDA and increase in SH and catalase levels in brain. The MNCV in diabetic rats (STZ-NA induced) treated with SSEA 200 and 400 mg kg-1 showed somewhat elevation in nerve conduction velocity as compared to that of diabetic rats. Transverse section of sciatic nerve showed changes due to diabetic nephropathy such as axonal swelling, derangement of nerve fibres which were reverted by 400 mg kg-1 of SSEA.
 
 
 
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