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Articles by Siti Balkis Budin
Total Records ( 4 ) for Siti Balkis Budin
  B. Hemabarathy , Siti Balkis Budin and Victor Feizal
  This study was conducted to observe the hepatoprotective effect of the crude extract of Alpinia galanga at 200 and 400 mg kg-1 against paracetamol induced hepatotoxicity in rats. Forty male Sprague-Dawley rats were divided into groups of four consisting of a control, 3000 mg kg-1 paracetamol as well as 200 and 400 mg kg-1 Alpinia galanga. The control group was orally fed with distilled water for eight days while the 3000 mg kg-1 paracetamol group was fed with distilled water for seven days followed by 3000 mg kg-1 paracetamol on day eight. The extract of Alpinia galanga was fed for seven days based on the respective doses followed by 3000 mg kg-1 paracetamol on day eight. Blood and liver samples were obtained from all the animals on the ninth day for biochemical analysis that includes total protein, aminotransferase enzymes (AST and ALT), malondialdehyde (MDA) and superoxide dismutase (SOD) as well as histological analysis (H and E staining). The results obtained showed that paracetamol given at the dose of 3000 mg kg-1 induced hepatotoxicity with significant decrease in serum protein levels and significant increase in serum AST and ALT levels as well as liver MDA levels at p<0.05. Supplementation with the extract of Alpinia galanga maintained serum protein and liver SOD levels similar to that of the normal control group. Significant decrease (p<0.05) in liver MDA levels as compared with the group treated with 3000 mg kg-1 paracetamol was observed in groups treated with the extract. Significant changes in MDA levels was also noted in group treated with 400 mg kg-1 Alpinia galanga against the group treated with 200 mg kg-1 Alpinia galanga. Histological analysis showed significant reduction in number of necrotic cells in both groups supplemented with the extract at p<0.05. The findings from the study showed that the crude extract of Alpinia galanga has protective effects against paracetamol induced hepatotoxicity.
  Jamaludin Mohamed , Wong Lik Wei , Nazratun Nafizah Akhtar Husin , Nasar Y. Alwahaibi and Siti Balkis Budin
  Selenium in the form of sodium selenite (SSE) is an essential micronutrient which known to possess antioxidant and anticancer properties. This study emphasizes the role of selenium on oxidative stress in experimental rats with N-diethylnitrosamine (DEN) initiated and 2-acetylaminofluorene (2-AAF) promoted multistage hepatocellular carcinogenesis (HCC). Rats were divided randomly into six groups: negative control, positive control (DEN+2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group (DEN+post-SSE 12 weeks) and therapeutic control (respective control for therapeutic group). SSE (4 mg L-1) was given to animals before initiation and during promotion phase of HCC. The levels of total protein (TP), conjugated diens (CD), malondialdehyde (MDA), fluorescent pigment (FP), antioxidant activity (AOA) and DNA damage were measured. Supplementation of SSE before the initiation phase of carcinogenicity significantly increased TP and AOA level (p<0.05) while it decreased the levels of CD, MDA, DNA damage and FP (p<0.05). Supplementation of SSE during the promotion phase of carcinogenicity significantly decreased the DNA damage and FP level (p<0.05) and there were negative correlation between the level of AOA and with the level of FP and CD. Thus, supplementation of SSE reduced the adverse changes which occur in liver cancer. However, the chemoprevention effect of SSE was more pronounced when it was supplemented before initiation phase of cancer when compared to promotion phase.
  Siti Balkis Budin , Cha Ming Han , Putri Ayu Jayusman and Izatus Shima Taib
  Fenitrothion (FNT) is extensively used as pesticide and may induce oxidative stress in various organs. Tocotrienol, a form of vitamin E found in palm oil, reduces oxidative impairments in pathological conditions. This study aims to investigate the effects of palm oil tocotrienol rich fraction (TRF) on fenitrothion-induced oxidative damage in rat pancreas. Forty male Sprague-Dawley rats were divided into four groups: control group, FNT group, TRF group and FNT+TRF group. Regimens FNT (20 mg kg-1 b.wt.) and TRF (200 mg kg-1 b.wt.) were force-fed for 28 consecutive days with control group only receiving corn oil. Chronic administration of fenitrothion significantly (p<0.05) induced oxidative damage in pancreas of rats with elevated malondialdehyde and protein carbonyl level. Depletion of glutathione and significant (p<0.05) reduction in antioxidant enzyme activities in pancreas homogenate additionally suggested induction of oxidative stress. Despite these changes in pancreas of intoxicated rats, no significant (p<0.05) changes in blood glucose and pancreas histology were observed. Co-administration of FNT with TRF alleviated these oxidative changes and significantly (p<0.05) restored antioxidant status. Enzymatic activities of Superoxide Dismutase (SOD) and Catalase (CAT) were normalized. In conclusion, tocotrienol rich fraction of palm oil prevents fenitrothion-induced pancreatic oxidative damage in rats.
  Rafidah Aini Pakri Mohamed , Norhayati Ibrahim , Siti Balkis Budin , Ahmad Marzuki Omar , Nor Azmi Kamaruddin and Rozmi Ismail
  Improved psychological aspect among type 2 diabetic patients plays an important role towards an improved quality of life. Therefore, the aim of this study is to determine the inter-relationship of illness perceptions, personality and quality of life of type 2 diabetic patients from the Diabetic Clinic of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A total of 115 of type 2 diabetic patients were involved in this study. Patients were surveyed using a quantitative questionnaires of Short Form 36 (SF-36), Revised-Illness Perception (IPQ-R) and big five inventory from September to December 2014. Result shows that most of the sub-domains in the Health Related Quality of Life (HRQOL) were correlated either positively or negatively with the sub-domain of illness perceptions (p<0.05). In addition, most of the sub-domains of the Big Five inventory were also positively correlated with the sub-domains of HRQOL except for the neuroticism sub-domain (p<0.05). It was also found that personality contributed 21.2% of the variation to the PCS domain while 32.6% of the variation contributed to the MCS domain of HRQOL. In addition, 17.1% of the illness perceptions variation contributed to the PCS domain and 32.7% of the variation contributed to the MCS domain of HRQOL. The findings of this study shows that there is a positive inter-relationship between illness perceptions and personality towards the quality of life of type 2 diabetic patients. A better understanding of illness perceptions and positive personality plays an important role in improving the quality of life among type 2 diabetic patients.
 
 
 
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