Ayten Yakut
Department of Pediatric Neurology, Faculty of Medicine,
Osmangazi University, Eskisehir, Turkey
Ener Cagr Dinleyici
Department of Pediatric , Faculty of Medicine,
Osmangazi University, Eskisehir, Turkey
Ozcan Bor
Department of Pediatric Hematology, Faculty of Medicine,
Osmangazi University, Eskisehir, Turkey
Coskun Yarar
Department of Pediatric , Faculty of Medicine,
Osmangazi University, Eskisehir, Turkey
Ahmet Ozer
Department of Opthalmology, Faculty of Medicine,
Osmangazi University, Eskisehir, Turkey
Serhat Ozkan
Department of Neurology, Faculty of Medicine,
Osmangazi University, Eskisehir, Turkey
ABSTRACT
Vitamin B12 deficiency can cause neurologic findings without anemia. Optic neuropathy due to vitamin B12 deficiency occurs occasionally in adult patients but it is rarely seen in children. A 16 year-old boy was followed up in the outpatient clinic with blurred vision. On physical examination, he had optic atrophy bilaterally without other neurologic findings. He had low levels of serum vitamin B12 and had no anemia. After cyanocobalamine treatment, visual acuity was improved but ophthalmologic findings were little changed despite serum vitamin B12 levels returned to be a normal. In conclusion, we want to draw attention that unexplained visual loss in childhood, especially in adolescence period, might be due to vitamin B12 deficiency and improvement of the visual symptoms is very well with vitamin B12 treatment. Optic atrophy without anemia may be the first sign of vitamin B12 deficiency.
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How to cite this article
Ayten Yakut, Ener Cagr Dinleyici, Ozcan Bor, Coskun Yarar, Ahmet Ozer and Serhat Ozkan, 2008. Optic Atrophy Due to Vitamin B12 Deficiency Without Anemia. Journal of Medical Sciences, 8: 188-190.
DOI: 10.3923/jms.2008.188.190
URL: https://scialert.net/abstract/?doi=jms.2008.188.190
DOI: 10.3923/jms.2008.188.190
URL: https://scialert.net/abstract/?doi=jms.2008.188.190
REFERENCES
- Aaron, S., S. Kumar, J. Vijayan, J. Jacob, M. Alexander and C. Gnanamuthu, 2005. Clinical and laboratory features and response to treatment in patients presenting with vitamin B12deficiency-related neurological syndromes. Neurol. India, 53: 55-58.
Direct Link - Areekul, S., C. Roongpisuthipong, K. Churdchu and W. Thanosomak, 1992. Optic neuropathy in a patient with vitamin B12 deficiency: A case report. J. Med. Assoc. Thai., 75: 715-718.
PubMed - Healton, E.B., D.G. Savage, J.C. Brust, T.J. Garrett and J. Lindenbaum, 1991. Neurologic aspects of cobalamin deficiency. Medicine, 70: 229-245.
Direct Link - Lindenbaum, J., E.B. Healton, D.G. Savage, J.C. Brust and T.J. Garrett et al., 1988. Neuropsychiatric disorders caused by cobalamine deficiency in the absence of anemia or macrocytosis. New Engl. J. Med., 318: 1720-1728.
PubMed - Moretti, R., P. Torre, R.M. Antonello, T. Cattaruzza, G. Cazzato and A. Bava, 2004. Vitamin B12 and folate depletion in cognition: A review. Neurol. India, 52: 310-318.
Direct Link - Moschos, M. and D. Droutsas, 1998. A man who lost weight and his sight. Lancet, 351: 1174-1174.
Direct Link - Rasmussen, S.A., P.M. Fernhoff and K.S. Scanlon, 2001. Vitamin B12 deficiency in children and adolescents. J. Pediatr., 138: 10-17.
Direct Link