Asian Journal of Applied Sciences1996-3343xxxx-xxxxKnowledgia Review10.3923/ajaps.2017.159.169MuthuselviChandran Shagaya PrincyArulanandam Sabapathy PandiarajanSankara 42017104Background and Objective: The crystal structure of title compound (4-Carboxyanilinium Dihydrogen Phosphate) was already reported. But in the best of the knowledge, there is no report on spectroscopy and antimicrobial activity studies of this compound. So objective of study was to grow the 4-carboxyanilinium dihydrogen phosphate complex crystal from slow evaporation technique and characterized by single crystal XRD, powder XRD, FTIR, FT-Raman, UV-Visible spectroscopy, SEM with EDX and antimicrobial activity studies. Materials and Methods: The title crystal (4-Carboxyanilinium Dihydrogen Phosphate Semi-Organic Complex Crystal) was obtained by slow evaporation technique from the aqueous ethanol solution of 4-aminobenzoic acid and orthophosphoric acid in 1:1 stoichiometric ratio. In this crystal growth process, 4-aminobenzoic acid, orthophosphoric acid, ethanol and deionized water were used as the raw materials which were purchased from Sigma Aldrich Company, India. Results: The crystal lattice parameters and space group was obtained from the single crystal XRD study. The powder X-ray diffraction peaks were indexed using the INDX software. The FTIR and FT-Raman spectra of 4-carboxyanilinium dihydrogen phosphate crystal have been recorded at room temperature. The spectra were interpreted in terms of these wavenumber assignments. The optical band gap was determined from the UV-Visible spectroscopy analysis. Also, the morphology and antimicrobial activity studies were performed on the title crystal. Conclusion: The title crystal has monoclinic crystal system with the space group P21/n. The average crystalline size is found to be as 54 nm. Further, the presence of functional groups and elements were verified using FTIR and FT-Raman spectroscopy and energy dispersive X-ray studies. The SEM analysis shows that the complex crystal has smooth surface and flower like morphology. The optical band gap is determined as 3.8 eV. The antimicrobial activity study shows that the complex crystal screened the bacteria than that of the parent crystal. This modified chemical structure may improve the solubility and reduce the toxicity of drug compound.]]>Overington, J.P., B. Al-Lazikani and A.L. Hopkins,20065993996British Pharmacopoeia,2009Electronic Version,Richards, R.M.E. and D.K. Xing,1995p-aminobenzoic acid on the uptake of thymidine and uracil by Escherichia coli.]]>116217221Akberova, S.I.,2002p-aminobenzoic acid.]]>29390393Benali-Cherif, N., F. Allouche, A. Direm and K. Soudani,200965o664o665Mazeaud, A., Y. Dromzee and R. Thouvenot,20001 syntheses, structure and reactivity of the Bis (tert-butylsilyl) decatungstophosphate [(γ-PW10O36)(t-BuSiOH) 2]3-.]]>3947354740Benali-Cherif, N., A. Direm, F. Allouche and K. Soudani,200763o2272o2274Benali-Cherif, N., A. Direm, F. Allouche and K. Soudani,200763o2054o2056Athimoolam, S. and S. Natarajan,200662o612o617Susindran, V., S. Athimoolam and S.A. Bahadura,2012446284636Muthuselvi, C., G. Sofiya and S. Pandiarajan,20179131139Colthup, N.B., L.H. Daly and S.E. Willely,19902nd Edn.,Bellamy, L.J.,19753rd Edn.,Anitha, R., S. Athimoolam, M. Gunasekaran and K. Anitha,20141076115125Nakamoto, K.,19861st Edn.,Muthuselvi, C., S. Pandiarajan and R.V. Krishnakumar,2016984067340678Muthuselvi, C., M. Dhavachitra and S. Pandiarajan,20168804814Koleva, V., V. Stefov, M. Najdoski and A. Cahil,20122PO4)2.2H2O.]]>62229237Rajkumar, B.J. and V. Ramakrishnan,200157247254Ravikumar, B., R.K. Rajaram and V. Ramakrishnan,200637597605