Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2017.44.48Abrus precatorius (Linn) on some Biochemical Parameters in Normal and Alloxan Induced Diabetic Rats]]>YusufuWakawa Henry TanimowoOluwayemisi AbubakarSa`adatu Aliyu AhmadFasihuddin Badruddin 22017122Objective: This study was targeted at valuing a claim by traditional herbal practitioners that the leaves of Abrus precatorius (Linn) possess hypoglycemic property by assessing the hypoglycemic effects of the aqueous extract of the leaves of Abrus precatorius (Linn) on some biochemical parameters in normal and alloxan-induced diabetic albino rats. Materials and Methods: Diabetes was induced by a single dose of intraperitoneal injection of 150 mg kg1 b.wt., of alloxan to 4 groups of experimental rats (group 2,3,4 and 5) and a daily oral administration of different concentrations 100, 200 and 400 mg kg1 b.wt., of the aqueous leaf extract of A. precatorius was administered to groups 3,4 and 5, respectively for 21 days based on traditional practices. Group 2 was used as diabetic control. Student t-test was used to determine the statistical difference between two mean values at 95% level of confidence (p<0.05) and glycemic index and liver marker enzymes were then measured. Results: The results of the study showed a significant decrease 18.90±0.81 (p<0.05) in the mean values of blood glucose and significant increase (p<0.05) in total bilirubin of the treated rats in both normal (16.65±3.29) and diabetic rats (17.60±0.2), it also showed an observed decrease in the mean values of aspartate transaminase, alanine transaminase and alkaline phosphatase in diabetic rats and an increase in the normal rats. Conclusion: The study indicates that the crude leaves extract of A. precatorius possesses hypoglycemic activity which is effective in glycemic control at dose 400 mg kg1 b.wt., it also possess potential toxic property as seen to affect the liver marker parameters, hence care should be taken when using the plant.]]>Ogbuehi, I.H., O.O. Ebong and A.W. Obianime,2015Abrus precatorius Linn leaves in wistar rats.]]>51825World Health Organization,1999Saganuwan, S., P.A. Onyeyili and A.O. Suleiman,2011Abrus precatorius leaf in Mus musculus.]]>573244Akinloye, B.A. and L.A. Adalumo,1981Abrus precatorius leaves-a source of glycyrrhizin.]]>12405405Karwasara, V.S., R. Jain, P. Tomar and V.K. Dixit,2010Abrus precatorius Linn.]]>46354362Wakawa, H.Y. and E.A. Franklyne,2015Abrus precatorius leaf extract against carbon tetrachloride- induced liver injury in rats.]]>51519Georgewill, O.A. and U.O. Georgewill,2009Abrus precatorious.]]>142325Anam, E.M.,2001Abrus precatorius (Fabaceae).]]>82427Monago, C.C. and O.F.C. Nwodo,2010Abrus precatorius Linn seed in alloxan diabetic rabbits.]]>319161919Attal, A.R., K.O. Otari, R.V. Shere, C.D. Upasani and T.D. Nandude,2010Abrus precatorius Linnaeus: A phytopharmacological review.]]>325852587Monago, C.C. and E.O. Alumanah,2005Abrus precatorius Linn seed in alloxan diabetic rabbit.]]>98588Shourie, A. and K. Kalra,2013Abrus precatorius L.]]>491101Gosh, R., K. Sharatchandra, S. Rita and I.S. Thokchom,2004Ficus hispida (bark) in normal and diabetic albino rats.]]>36222225Nair, S.A., B.S. Shylesh, B. Gopakumar and A. Subramoniam,2006Hemionitis arifolia (Burm.) Moore in rats.]]>106192197Ramachandran, A., A.K. Das, S.R. Joshi, C.S. Yajnik, S. Shah and K.M. Prasanna,20105879Malvi, R., S. Jain, S. Khatri and S. Mishra,2011213441355Alli, A.I., J.O. Ehinmidu and Y.K.E. Ibrahim,201141016Kato, G.J., V. McGowan, R.F. Machado, J.A. Little and J. Taylor et al.,200610722792285Sorbi, D., J. Boynton and K.D. Lindor,19999410181022Sarac, F., F. Saygili, G. Ozgen, M. Tuzun, C. Yilmaz and T. Kabalak,200763126131Lucchesi, A.N., L.L. Cassettari and C.T. Spadella,20152015Nsiah, K., V.P. Dzogbefia, D. Ansong, A.O. Akoto, H. Boateng and D. Ocloo,2011419Adedapo, A.A., O.A. Omolove and O.G. Ohore,2007Abrus precatorius in rats.]]>743136Wakawa, H.Y., E.O. Adejo and B.A. Fasihuddin,2015331373142