Asian Journal of Clinical Nutrition1992-14702077-2033Asian Network for Scientific Information10.3923/ajcn.2017.89.96SariDina Keumala TalaZaimah Zulkarnaini LestariSri HutagalungSunna Vyatra GanieRatna Akbari 2201792Background and Objective: Women living in the tropical regions, including those from North Sumatera, Indonesia, are shown to experience a vitamin D deficiency. Predisposing factors include Vitamin D Receptor (VDR) gene polymorphisms and low vitamin D intakes. The objective of this study was to assess the effect on women with a VDR gene polymorphism (TaqI and BsmI) of 28 days supplementation with 1000 IU vitamin D day1 on serum 25-hydroxyvitamin D (25(OH)D) and calcium. Methodalogy: The study was an open parallel-group randomized clinical trial involving 40 women from North Sumatera with a VDR gene polymorphism, recruited using specific criteria. The subjects were divided into two groups of 20 using a randomized block design. The intervention (D) group received 1000 IU vitamin D day1 and dietary counseling for 28 days and the control (C) group received a placebo and dietary counseling for 28 days. Serum 25(OH) D and calcium were measured on day 0 and 28. SPSS version 11.5 was used for statistical analysis p<0.05. Results: The study was completed by 19 D group subjects and 17 C-group subjects. The intervention resulted in a significant increase in serum 25(OH) D in the D group (p = 0.04) and no change in serum 25(OH) D the C group. At the end of the intervention, the D group had significantly higher serum 25(OH) D than the C group (p = 0.04) but no subjects with a vitamin D status of deficient or insufficiency were elevated to a status of sufficient from either group. Conclusion: The results revealed that vitamin D deficiency can occur in women with a VDR gene polymorphism even after 28 days supplementation with 1000 IU vitamin D/day.]]>Vieth, R.,200613611171122Sari, D.K., H.A. Damanik, N.I. Lipoeto and Z. Lubis,20132013Keumala, S.D., D.H. Alrasyid, L. Nurindrawaty and L. Zulkifli,2014206370Khor, G.L., W.S.S. Chee, Z.M. Shariff, B.K. Poh, M. Arumugam, J.A. Rahman and H.E. Theobald,20112011Masood, S.H. and M.P. Iqbal,200824891897Harinarayan, C.V. and S.R. Joshi,2007574048Setiati, S., M. Oemardi, B. Sutrisna and Supartondo,20072126132Macdonald, H.M., A. Mavroeidi, R.J. Barr, A.J. Black, W.D. Fraser and D.M. Reid,2008429961003Ardawi, M.S.M., A.M. Sibiany, T.M. Bakhsh, M.H. Qari and A.A. Maimani,201223675686Shea, M.K., D.K. Houston, J.A. Tooze, C.C. Davis and M.A. Johnson et al.,20115911651174Rajakumar, K., J. de las Heras, T.C. Chen, S.J. Lee, M.F. Holick and S.A. Arslanian,20119615601567Bolland, M.J., A.B. Grey, R.W. Ames, B.H. Mason, A.M. Horne, G.D. Gamble and I.R. Reid,20061717421748Lagunova, Z., A.C. Porojnicu, F. Lindberg, S. Hexeberg and J. Moan,20092937133720McKinney, K., C.R. Breitkopf and A.B. Berenson,200869535541Kull, M., R. Kallikorm and M. Lember,200939256258Goldner, W.S., J.A. Stoner, J. Thompson, K. Taylor, L. Larson, J. Erickson and C. McBride,200818145150Nikooyeh, B., T.R. Neyestani, M. Farvid, H. Alavi-Majd and A. Houshiarrad et al.,201193764771Schleithoff, S.S., A. Zittermann, G. Tenderich, H.K. Berthold, P. Stehle and R. Koerfer,200683754759Sari, D.K., Z.Z. Tala, S. Lestari, S.V. Hutagalung and R.A. Ganie,201793743Sari, D.K., Z.Z. Tala, S. Lestari, S.V. Hutagalung and R.A. Ganie,201794450Bouillon, R., G. Eelen, L. Verlinden, C. Mathieu, G. Carmeliet and A. Verstuyf,2006102156162Nagpal, J., J.N. Pande and A. Bhartia,20093 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men.]]>261927Rosenblum, J.L., V.M. Castro, C.E. Moore and L.M. Kaplan,201295101108Anonymous,20162016Gill, T.,200615314Erhardt, J. and R. Gross,20072007Corrigan, M.L.,20172017pp: 89-90pp: 89-90Kelley, W.M. and R.A. Donnelly Jr.,2009Pages: 560Pages: 560Litch, M.D.,20172017pp: 107pp: 107Holick, M.F.,2007357266281Holick, M.F.,200829361368Autier, P. and S. Gandini,200716717301737