Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2009.3407.3423DehwahMustafa Abdo Saif ShuangZhang HuaWang Zhen MinWang HuangQing-Yang 122009919The aim of this review was to discuss the current understanding of Type 2 Diabetes Mellitus (T2DM) genetic advance and aetiology. The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Earlier studies using a candidate gene approach, family linkage studies and gene expression profiling uncovered a number of T2DM genes, but the genetic basis of common T2DM remained unknown. Recent years have seen a tremendous surge in our understanding of the genetics of T2DM by Genome-Wide Association Study (GWAS). Approximately 20 genes consistently associated with T2DM mainly implicate pancreatic β-cell function in the pathogenesis of T2DM.]]>Abate, N., M. Chandalia, P. Satija, B. Adams-Huet and S.M. Grundy et al.,20015412071213Altshuler, D., J.N. Hirschhorn, M. Klannemark, C.M. Lindgren and M.C. Vohl et al.,2000267680Arfa, I., A. Abid, D. Malouche, N. Ben Alaya and T.R. Azegue et al.,200783348351Aulchenko, Y.S., J. Pullen, W.P. Kloosterman, M. Yazdanpanah and A Hofman et al.,20075630203026Babenko, A.P., M. Polak, H. Cave, K. Busiah and P. Czernichow et al.,2006355456466Bacci, S., O. Ludovico, S. Prudente, Y.Y. Zhang and R. Di Paola et al.,20055430213025Baier, L.J., P.A. Permana, X. Yang, R.E. Pratley and R.L. Hanson et al., 2000106R69R73Barnett, A.H., C. Eff, R.D.G. Leslie and D.A. Pyke,1981208793Barroso, I., J. Luan, R.P. Middelberg, A.H. Harding and P.W. Franks et al.,20031e20e20Bento, J.L., N.D. Palmer, J.C. Mychaleckyj, L.A. Lange and C.D. Langefeld et al.,20045330073012Bingham, C., S. Ellard, L. Allen, M. Bulman and M. Shepherd et al.,200057898907Bonnycastle, L.L., C.J. Willer, K.N. Conneely, A.U. Jackson and C.P. Burrill et al.,20065525342540Bouatia-Naji, N., A. Bonnefond, C. Cavalcanti-Proença, T. Sparsø and J. Holmkvist et al.,2009418994Chang, Y.C., T.J. Chang, Y.D. Jiang, S.S. Kuo, K.C. Lee, K.C. Chiu and L.M. Chuang,20075626312637Cauchi, S., D. Meyre, C. Dina, H. Choquet and C. Samson et al.,20065529032908Cauchi, S., Y. El Achhab, H. Choquet, C. Dina and F. Krempler et al.,200785777782Damcott, C.M., T.I. Pollin, L.J. Reinhart, S.H. Ott and H. Shen et al.,2006TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance.]]>5526542659Deeb, S.S., L. Fajas, M. Nemoto, J. Pihlajamäki and L. Mykkänen et al.,199820284287Dehwah, M.A.S., Z. Shuang, W. Yan, P. Chan and Q.Y. Huang,2008812351241Demenais, F., T. Kanninen, C.M. Lindgren, S. Wiltshire and S. Gaget et al.,20031218651873De Silva, S.N., N. Weerasuriya, N.M. De Alwis, M.W. de Silva and D.J. Fernando,200258173177De Sousa, A.G., C. Cercato, M.C. Mancini and A. Halpern,20089340354Dina, C., D. Meyre, S. Gallina, E. Durand and A. Korner et al.,200739724726Elbein, S.C., J. Sun, E. Scroggin, K. Teng and S.J. Hasstedt,200124472478Fajans, S.S., G.I. Bell and K.S. Polonsky,2001345971980Florez, J.C., N. Burtt, P.I. de Bakker, P. Almgren and T. Tuomi et al.,20045313601368Florez, J.C., C.M. Agapakis, N.P. Burtt, M. Sun and P. Almgren et al.,20055418841891Florez, J.C., A.K. Manning, J. Dupuis, J. McAteer and K. Irenze et al.,20075630633074Franks, P.W., O. Rolandsson, S.L. Debenham, K.A. Fawcett and F. Payne et al., 200851458463Frayling, T.M., N.J. Timpson, M.N. Weedon, E. Zeggini and R.M. Freathy et al.,2007316889894Frayling, T.M.,20078657662Frayling, T.M., H. Colhoun and J.C. Florez,20085117571760Gibson, F. and P. Froguel,20045329772983Gloyn, A.L., M.N. Weedon, K.R. Owen, M.J. Turner and B.A. Knight et al.,200352568572Gloyn, A.L., E.R. Pearson, J.F. Antcliff, P. Proks and G.J. Bruining et al.,200435018381849Grant, S.F., G. Thorleifsson, I. Reynisdottir, R. Benediktsson and A. Manolescu et al., 2006TCF7L2) gene confers risk of type 2 diabetes.]]>38320323Grarup, N., C.S. Rose, E.A. Andersson, G. Andersen and A.L. Nielsen et al.,20075631053111Grarup, N., G. Andersen, N.T. Krarup, A. Albrechtsen and O. Schmitz et al., 20085725342540Groop, L.C. and T. Tuomi,1997293753Groves, C.J., E. Zeggini, J. Minton, T.M. Frayling and M.N. Weedon et al.,20065526402644Gudmundsson, J., P. Sulem, V. Steinthorsdottir, J.T. Bergthorsson and G. Thorleifsson et al.,200739977983Hansen, T., S.M. Echwald, L. Hansen, A.M. Møller and K. Almind et al.,199847598605Hani, E.H., J. Hager, A. Philippi, F. Demenais, P. Froguel and N. Vionnet,19974612251226Hanson, R.L., C. Bogardus, D. Duggan, S. Kobes and M. Knowlton et al.,20075630453052Hart, L.M., P. de Knijff, J.M. Dekker, R.P. Stolk and G. Nijpels et al.,199942617620Hayes, M.G., A. Pluzhnikov, K. Miyake, Y. Sun and M.C.Y. Ng et al., 20075630333044Hegele, R.A., F. Sun, S.B. Harris, C. Anderson, A.J. Hanley and B. Zinman,1999441014Helgadottir, A., G. Thorleifsson, A. Manolescu, S. Gretarsdottir and T. Blondal et al.,200731614911493Herder, C., W. Rathmann, K. Strassburger, H. Finner and H. Grallert et al.,200840722726Holmkvist, J., P. Almgren, V. Lyssenko, C.M. Lindgren and K.F. Eriksson et al.,20085717381744Horikawa, Y., N. Oda, N.J. Cox, X. Li and M. Orho-Melander et al.,200026163175Hu, C., C. Wang, R. Zhang, X. Ma and J. Wang et al.,20095213221325Huang, Q.Y., M.R. Cheng and S.L. Ji,200633573589Inoue, H., J. Ferrer, C.M. Welling, S.C. Elbein and M. Hoffman et al.,199645825831Inoue, H., J. Ferrer, M. Warren-Perry, Y. Zhang and H. Millns et al.,199746502507Janssens, A.C., Y.S. Aulchenko, S. Elefante, G.J. Borsboom, E.W. Steyerberg and C.M. van Duijn,20068395400Janssens, A.C., R. Moonesinghe, Q. Yang, E.W. Steyerberg, C.M. van Duijn and M.J. Khoury,20079528535Janssens, A.C.J.W. and C.M. van Duijn,200817R166R173Kashyap, S.R. and R.A. DeFronzo,200741319King, H. and M. Rewers,199316157177Kissebah, A.H., G.E. Sonnenberg, J. Myklebust, M. Goldstein and K. Broman et al.,2000971447814483Knowler, W.C., R.C. Williams, D.J. Pettitt and A.G. Steinberg,198843520526Krishnamurthy, J., M.R. Ramsey, K.L. Ligon, C. Torrice, A. Koh, S. Bonner-Weir and N.E. Sharpless,2006443453457Lango, H., C.N.A. Palmer, A.D. Morris, E. Zeggini and A.T. Hattersley et al.,20085731293135Lee, Y.H., E.S. Kang, S.H. Kim, S.J. Han and C.H. Kim et al.,200853991998Li, S., L. Li, K. Li, X. Qi, D. Hoekema, H. Liu and G. Yang, 200868885889Lin, X., K. Song, N. Lim, X. Yuan and T. Johnson et al.,200952600608Lindner, T.H., P.R. Njolstad, Y. Horikawa, L. Bostad, G.I. Bell and O. Sovik,1999820012008Liu, Y., L. Yu, D. Zhang, Z. Chen and D.Z. Zhou et al.,2008CDKAL1 and type 2 diabetes in Han Chinese individuals.]]>5121342137Liu, Y., D.Z. Zhou, D. Zhang, Z. Chen and T. Zhao et al.,2009KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China.]]>5213151321Love-Gregory, L., J. Wasson, J. Lin, G. Skolnick, B. Suarez and M.A. Permutt,200346136137Love-Gregory, L.D., J. Wasson, J. Ma, C.H. Jin, B. Glaser, B.K. Suarez and M.A. Permutt,20045311341140Ludovico, O., F. Pellegrini, R. Di Paola, A. Minenna and S. Mastroianno et al.,20071510761081Lyssenko, V., P. Almgren, D. Anevski, M. Orho-Melander and M. Sjogren et al.,20052e345e345Lyssenko, V., R. Lupi, P. Marchetti, S. Del Guerra and M. Orho-Melander et al.,200711721552163Lyssenko, V., A. Jonsson, P. Almgren, N. Pulizzi and B. Isomaa et al.,200835922202232Lyssenko, V., C.L. Nagorny, M.R. Erdos, N. Wierup and A. Jonsson et al.,2009418288Marchini, J., B. Howie, S. Myers, G. McVean and P. Donnelly,200739906913Matsuoka, N., A. Patki, H.K. Tiwari, D.B. Allison and S.B. Johnson et al.,200630233237McPherson, R., A. Pertsemlidis, N. Kavaslar, A. Stewart and R. Roberts et al.,200731614881491Meirhaeghe, A., N. Helbecque, D. Cottel, D. Arveiler and J.B. Ruidavets et al.,200110148Minton, J.A.L., A.T. Hattersley, K. Owen, M.I. McCarthy and M. Walker et al.,20025112871290Miyake, K., W. Yang, K. Hara, K. Yasuda and Y. Horikawa et al.,200954236241Muhlbauer, E. and E. Peschke,200742105106Newman, B., J.V. Selby, M.C. King, C. Slemenda, R. Fabsitz and G.D. Friedman,198730763768Ng, M.C.Y., C.H.T. Tam, V.K.L. Lam, W.Y. So, R.C.W. Ma and J.C.N. Chan,2007TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.]]>9237333737Ng, M.C., K.S. Park, B. Oh, C.H. Tam and Y.M. Cho et al.,20085722262233Nielsen, E.M., L. Hansen, B. Carstensen, S.M. Echwald and T. Drivsholm et al.,200352573577Nishigori, H., S. Yamada, T. Kohama, H. Tomura and K. Sho et al.,19984713541355Omori, S., Y. Tanaka, A. Takahashi, H. Hirose and A. Kashiwagi et al.,200857791795Palmer, N.D., J.L. Bento, J.C. Mychaleckyj, C.D. Langefeld and J.K. Campbell et al.,20045330133019Palmer, N.D., M.O. Goodarzi, C.D. Langefeld, J. Ziegler and J.M. Norris et al.,20085710931100Pandi-Perumal, S.R., I. Trakht, V. Srinivasan, D.W. Spence, G.J. Maestroni, N. Zisapel and D.P. Cardinali,200885335353Parker, A., J. Meyer, S. Lewitzky, J.S. Rennich and G. Chan et al.,200150675680Pascoe, L., A. Tura, S.K. Patel, I.M. Ibrahim and E. Ferrannini et al.,20075631013104Peschke, E.,2008442640Peterfy, M., J. Phan, P. Xu and K. Reue,200127121124Phan, J., M. Peterfy and K. Reue,2004in vivo and in vitro.]]>2792955829564Prokopenko, I., C. Langenberg, J.C. Florez, R. Saxena and N. Soranzo et al.,2009417781Rampersaud, E., C.M. Damcott, M. Fu, H. Shen and P. McArdle et al.,20075630533062Ramracheya, R.D., D.S. Muller, P.E. Squires, H. Brereton and D. Sugden et al.,200844273279Reppert, S.M., C. Godson, C.D. Mahle, D.R. Weaver, S.A. Slaugenhaupt and J.F. Gusella,19959287348738Reynisdottir, I., G. Thorleifsson, R. Benediktsson, G. Sigurdsson and V. Emilsson et al.,200373323335Ridderstråle, M. and L. Groop,20092971017Rong, R., R.L. Hanson, D. Ortiz, C. Wiedrich, S. Kobes, W.C. Knowler, C. Bogardus and L.J. Baier,200958478488Sakura, H., N. Wat, V. Horton, H. Millns, R.C. Turner and F.M. Ashcroft,1996in vitro.]]>3912331236Salonen, J.T., P. Uimari, J.M. Aalto, M. Pirskanen and J. Kaikkonen et al.,200781338345Sandhu, M.S., M.N. Weedon, K.A. Fawcett, J. Wasson and S.L. Debenham et al.,200739951953Sanghera, D.K., L. Been, L. Ortega, G.S. Wander and N.K. Mehra et al.,200954162168Saxena, R., L. Gianniny, N.P. Burtt, V. Lyssenko and C. Giuducci et al.,20065528902895Saxena, R., B.F. Voight , V. Lyssenko , N.P. Burtt and P.I. de Bakker et al.,200731613311336Scott, L.J., L.L. Bonnycastle, C.J. Willer, A.G. Sprau and A.U. Jackson et al.,20065526492653Schwanstecher, C., U. Meyer and M. Schwanstecher,200251875879Scott, L.J., K.L. Mohlke, L.L. Bonnycastle, C.J. Willer, Y. Li and W.L. Duren et al.,200731613411345Serjeantson, S.W., D. Owerbach, P. Zimmet, J. Nerup and K. Thoma,1983251317Shimomura, I., R.E. Hammer, S. Ikemoto, M.S. Brown and J.L. Goldstein,19994017376Silander, K., K.L. Mohlke, L.J. Scott, E.C. Peck and P. Hollstein et al.,20045311411149Sladek, R., G. Rocheleau, J. Rung, C. Dina and L. Shen et al.,2007445881885Staiger, H., F. Machicao, N. Stefan, O. Tschritter and C. Thamer et al.,20072e832e832Staiger, H., A. Stancakova, J. Zilinskaite, M. Vänttinen and T. Hansen et al.,200857514517Steinthorsdottir, V., G. Thorleifsson, I. Reynisdottir, R. Benediktsson and T. Jonsdottir et al.,200739770775Tabara, Y., H. Osawa, R. Kawamoto, H. Onuma and I. Shimizu et al.,200958493498Thomas, F., B. Balkau, F. Vauzelle-Kervroedan and L. Papoz,1994436367Thomas, G., K.B. Jacobs, M. Yeager, P. Kraft, S. Wacholder et al.,200840310315Tong, Y., Y. Lin, Y. Zhang, J. Yang, Y. Zhang, H. Liu and B. Zhang,2009101515Ubeda, M., J.M. Rukstalis and J.F. Habener,20062812885828864Unoki, H., A. Takahashi, T. Kawaguchi, K. Hara and M. Horikoshi et al.,20084010981102Van den Ouweland, J.M., H.H. Lemkes, R.C. Trembath, R. Ross and J.A. Maassen et al.,199443746751Van Hoek M., A. Dehghan, J.C Witteman, C.M.V. Duijn and A.C. Janssens et al.,20085731223128Van Tilburg, J.H., L.A. Sandkuijl, E. Strengman, H.V. Someren and C. Wijmenga et al.,20038822232230Vaxillaire, M., J. Veslot, C. Dina, C. Proença and S. Cauchi et al.,200857244254Vionnet, N., E.H. Hani, S. Dupont, S. Gallina and S. Francke et al.,20006714701480Wang, H., W. Chu, S.K. Das, Q. Ren, S.J. Hasstedt and S.C. Elbein,20025128612865Weedon, M.N., P.E. Schwarz, Y. Horikawa, N. Iwasaki and T. Illig et al.,20037312081212Weedon, M.N., M.I. McCarthy, G. Hitman, M. Walker and C.J. Groves et al.,20062006Wei, F.Y., K. Nagashima, T. Ohshima, Y. Saheki and Y.F. Lu et al.,20051111041108Winckler, W., M.N. Weedon, R.R. Graham, S.A. McCarroll and S. Purcell et al.,200756685693Wray, N.R., M.E. Goddard and P.M. Visscher,20071715201528Wu, Y., H. Li, R.J. Loos, Z. Yu and X. Ye et al.,20085728342842Yang, Q., M.J. Khoury, L. Botto, J.M. Friedman and W.D. Flanders, 200372636649Yasuda, K., K. Miyake, Y. Horikawa, K. Hara and H. Osawa et al.,20084010921097Yokoi, N., M. Kanamori, Y. Horikawa, J. Takeda and T. Sanke et al.,20065523792386Zacharova, J., J.L. Chiasson, M. Laakso and S.N. Study Group,200554893899Zeggini, E., M.W. Weedon, C.M. Lindgren, T.M. Frayling and K.S. Elliott et al.,200731613361341Zeggini, E., L.J. Scott, R. Saxena, B.F. Voight and J.L. Marchini et al.,200840638645Zhang, C., L. Qi , D.J. Hunter, J.B. Meigs, J.E. Manson, R.M. van Dam and F.B. Hu,20065526452648Zhou, J. and T.L. Young, 20053521019Zhu, Q., K. Yamagata, A. Miura, N. Shihara and Y. Horikawa et al.,200346567573Zouali, H., E.H. Hani, A. Philippi, N. Vionnet, J.S. Beckmann, F. Demenais and P. Froguel,1997614011408