Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2008.426.430Rosa damascena on the PTZ Induced Seizures in Wistar Rats]]>KheirabadiMasoumeh MoghimiAli RakhshandeHassan RassouliMorteza Behnam 2200882The goal of the present study was to evaluate the anticonvulsant property of Rosa damascena essence as a natural origin compound on the PTZ induced seizures in rats. To produce animal models with different graded of seizures (partial to generalized tonic-clonic seizures), PTZ was injected in 40 male Wistar rats. Prior to PTZ injections, the experimental groups of rats were received 500, 750 and 1000 mg kg-1 body weight essential oil. During the experimental period the epileptiform behaviors of all rats of different groups, was evaluated before and after essential injections. The results showed that the Rosa essential can attenuate the latent periods of the beginning of convulsions as well as the severity of seizures in a dose dependent manner. The flavonoids of Rosa damascena may act via GABAA receptors as pervious studies have proposed for flavonoids of other medicinal plants.]]>Achuthan, C.R., B.H. Babu and J. Padikkala,2003Rosa damascena.]]>41357361Basim, E. and H. Basim,2004Rosa damascena on Erwinia amylovora.]]>324409412Boskabady, M.H., S. Kiani and H. Rakhshandah,2006106377382Dekermendjian, K., P. Khanberg, M.R. Witt, O. Sterner, M. Nielsen and T. Liljefors,19994243434350Erica, L., Campbel, M.C. Graham and A.R. Johnston,20046816311638Fisher, R.S.,200514245278Jefferys John, G.R.,2003444460Kandel, E.R., J.H. Schwartz and T.M. Jessell,20004th Edn.,pp: 1228-1245pp: 1228-1245Loghmani-Khouzani, H., O. Sabzi Fini and J. Safari,2007Rosa damascena mill cultivated in central Iran.]]>14316319Mahmood, N., S. Piacente, C. Pizza, A. Burke, A.I. Khan and A.J. Hay,1996Rosa damascena.]]>2297379Mahmoodi, M., A. Zohoor and M. Asadi,20036212213Marder, M. and A.C. Paladini,20022853867Matthew, P. and C. Charles,200310287295Ozkan, G., O. Sagdic, N.G. Baydar and H. Baydar,2004Rosa damascena flower extracts.]]>10277281Paladini, A.C., M. Marder, H. Viola, C. Wolfman, C. Wasowski and J.H. Medina,199951519526Rakhshandeh, H., M. Hosseini and K. Dolati,2004Rosa damascena in mice.]]>3181185Rakhshandeh, H., N. Vahdati-mashhadian, K. Dolati and M. Hosseini,2008Rosa damascena in Mice.]]>8176180Sarkisian, M.R.,20012201216Shafei, M.N., H. Rakhshandah and M.H. Boskabady,2003Rosa damascena in Guinea pigs.]]>2231234Sugiyama, K., T. Muteki and T. Kano,1996A receptors of rat sensory neurons in culture.]]>216147150Tisserand, R. and T. Balacs,1995pp: 204-210pp: 204-210Wie, M.B., M.H. Won, K.H. Lee, J.H. Shin, J.C. Lee, et al.,19962259398Zargari, A.,19925th Edn.,pp: 281-285pp: 281-285