Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2005.337.343Carica papaya Seed on Oestrous
Cycle and Fertility in Female Albino Rats]]>RajiY. MorakinyoA.O. OloyoA.K. AkinsomisoyeO.S. .Olufadekemi Kunle-AlabiT. Esegbue-PetersP.R.C. AwobajoF.O. 4200554The impact of oral administration of 100 mg kg 1 b.w of chloroform
extract of Carica papaya seed (CPE) on oestrous cycle, fertility and
serum 17 -oestradiol levels, in female rats was investigated. Ten proestrous
rats received 2.5% tween 80 in normal saline (vehicle for CPE) and served as the
control in each part of the study. In the oestrous cycle study, ten proestrous
rats were treated with CPE for 14 days. The phases and frequencies of the
oestrous cycles of the rats were determined daily for another 14 days while CPE
treatment continued. In the fertility study, ten proestrous rats were treated as
in the oestrous cycle study for 14 days and were thereafter cohabited with
fertile untreated male rats for another 14 days while CPE treatment lasted. CPE
did not adversely affect body weight of the rats. However there was a
significant decrease (p<0.05) in the weight of the ovary, but not in the
uterus. There was a significant decrease (p<0.01) in serum 17 -oestradiol
levels in CPE treated rats. The oestrous cycle became irregular, with prolonged
diestrous phase from the 3rd week of CPE treatment. There were disorganization
and degeneration in the ovary. The uterus showed signs of vacuolation and mild
disorganization. The extract treated rats produced a significant decrease in
litter number (p<0.01) but the fetal weight and morphology remain unchanged
relative to the control. The results suggest that chloroform extract of Carica
papaya seed has antifertility properties, possibly acting via inhibition of
oestrogen secretion.]]>Raji, Y. and A.F. Bolarinwa,1997Quassia amara inmale rats in vivo study.]]>6410671074Parveen, S., S. Das, C.P. Kundra and B.M.J. Perreira,2003Quassia amara in male rats.]]>174550Raji, Y., U.S. Udoh, O.O. Mewoyeka, F.C. Ononye and A.F. Bolarinwa,2003Azadirachta indica extract in rats.]]>32159165McNeil, R.T., C.C. Noronha, T.O. Kusemiju and A.O. Okanlawon,2003Ricinus communis Linn.]]>23134Chinoy, N.J., J.M.D. Sonza and P. Padman,1984Carica papaya seed in male albino rat.]]>87579Lohiya, N.K., B. Manivannan, P.K. Mishra and N. Pathak,20012001pp: 99-119pp: 99-119Lohiya, N.K., B. Manivannam, P.K. Mishra, N. Pathak, S. Sririam, S.S. Bhande and S. Panneerdoss,2002Carica papaya seeds induces long-term reversible azoospermia in Langur monkey. ]]>411726Chinoy, N.J. and S.M. George,1983Carica papaya seed extract treatment.]]>14425432Kusemiju, O., C. Noronha and O.A. Okanlawon,2002Carica papaya on the seminiferous tubules of male Sprague-Dawley rats.]]>9205209Cherian, T.,2000Papaya latex extract on grand and non-gravid rat uterus preparations in vitro.]]>70205212Eno, A.E., O.I. Owo, E. Itam and R.S. Konya,2000Carica papaya (I) in renal and DOCA-induced hypertension in the rat.]]>14235239Biswas, N.M., P.B. Patra, S. Sanyal and C. Deb,19792227233Favaretto, A.L., M.M. Valenca, M. Hattori, K. Wakabayashi and J. Autunes-Rodrigues,199821539543Mayerhofer, A., A.G. Amador, R.W. Stager, J.G.M. Shire and A. Batke,199315417424Van Denmark, N.L. and L.J. Boyd,199681245247Lucidi, P., N. Bernabo, M. Turriani, M. Mattioli and B. Barboni,2003Cumulus steroidogenesis is influenced by the degree of oocyte maturation.]]>14555Knuth, U.A., M.G. Hull and H.S. Jacobs,197784801807Schwartz, N.B.,196925155Qian, S.Z.,1987pp: 217-232pp: 217-232Morton, J.,1987pp: 336-346pp: 336-346Raji, Y., A.O. Morakinyo, O.S. Akinsomisoye, A.K. Oloyo, P.R.C. Esegbue-Peters and O.T. Kunle-Alabi,2006Carica papaya L. seed in female albino rats.]]>22023