Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2015.25.31Zingiber officinale Extract against Histopathological and Ki-67 Immunohistochemical Changes of Glycerol-Induced Acute Renal Failure in Rat]]>KottAttalla F. El- BakryKadry A. Al- EltantawyWaleed A. 12015151The purpose of this study was to investigate the protective effects of ginger extract on the glycerol-induced acute kidney failure. Forty eight male Sprague-Dawley rats which divided randomly into four equal groups of 12 animals each; Group I: Normal; Group II: Received ginger extract at a dose of 400 mg kg-1 b.wt. per day by gavage; Group III: Received hypertonic glycerol (50%, v/v in sterile saline) was injected i.m. at a dose of 10 mL kg-1 and Group IV: Ginger extract, given orally at a dose of 400 mg kg-1 b.wt. per day for 30 days and injected i.m. with 10 mL kg-1 of hypertonic glycerol. The results showed that serum creatinine, Na+ and blood urea nitrogen were markedly increased in glycerol-treated rats and creatinine clearance was decreased. It is proved that ginger extract reduced their levels significantly. This study confirmed the glycerol-induced acute renal failure in terms of inflammatory infiltrate with clusters of neutrophil cells, sever hemorrhage, necrosis of some renal tubule cells together with karyolytic and pyknotic nuclei. Also, degenerated glomeruli and widening of the urinary space were noticed, deposition of intraluminal PAS positive hyaline casts and loss of the apical brush borders and decreased Ki-67 proliferation marker. The labeling index of Ki-67 in this study showed that in control group (47.3+4.6), in ginger extract group (68.7+5.16), in ARF group (35.4+4.3) and ARF treated with ginger extract group (68.9+6.2) were positively stained. However, all these adverse effects were reversed by ginger supplementation. Thus, this study suggests that ginger can be used as a nephro-protective nutrient and protect the kidney from glycerol-induced damage.]]>Afzal, M., D. Al-Hadidi, M. Menon, J. Pesek and M.S.I. Dhami,200118159190Ahmed, R.S., S.G. Suke, V. Seth, A. Chakraborti, A.K. Tripathi and B.D. Banerjee,2008Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats.]]>22902906Ajith, T.A., M.S. Aswathy and U. Hema,20084631783181Akhani, S.P., S.L. Vishwakarma and R.K. Goyal,200456101105Bhandari, U., J. Ahmed and K.K. Pillai,2001442832Boudville, N., G.R. Prasad, G. Knoll, N. Muirhead, H. Thiessen-Philbrook and R.C. Yang et al.,2006145185196Cheung, A.K., L.L. Wu, C. Kablitz and J.K. Leypoldt,199322271276Duke, J.A.,20102nd Edn.,Pages: 896Pages: 896Foster, S.,2012Pages: 470Pages: 470Gai, Z., L. Chu, C. Hiller, D. Arsenijevic and C.A. Penno et al.,2014306F130F137Guidet, B. and S.V. Shah,19892O2 generation by rat kidney in glycerol-induced renal failure.]]>257F440F445James, M.T., B.R. Hemmelgarn and M. Tonelli,201037512961309Jimenez, F., M.J. Monte, M.Y. El-Mir, M.J. Pascual and J.J.G. Marin,20024723982406Joshi, S.C. and P.K. Jain,20143357380Khejonnit, V., B. Pratumvinit, K. Reesukumal, S. Meepanya, C. Pattanavin and P. Wongkrajang,201543914Kim, H.W., A. Murakami, M. Abe, Y. Ozawa, Y. Morimitsu, M.V. Williams and H. Ohigashi,2005716211629Krishnakantha, T.P. and B.R. Lokesh,199330133134Mak, R.H.K. and R.A. De Fronzo,199261377382Marenzi, G., N. Cosentino, J.P. Werba, C.C. Tedesco, F. Veglia and A.L. Bartorelli,20151834753Nadasdy, T., Z. Laszik, K.E. Blick, L.D. Johnson and F.G. Silva,1994420322039Nugent, R.A., S.F. Fathima, A.B. Feigl and D. Chyung,2010118c269c277Pan, M.H., M.C. Hsieh, J.M. Kuo, C.S. Lai, H. Wu, S. Sang and C.T. Ho,200852527537Ramudu, S.K., M. Korivi, N. Kesireddy, C.Y. Chen, C.H. Kuo and S.R. Kesireddy,201121263270Rao, S., J.R. Brandt, A. Staples and H. Agarwal,201563204204Saeid, J.M., A.B. Mohamed and M.A. Al-Baddy,2010Zingiber officinale) on blood biochemistry parameters of broiler.]]>9944947Sertie, J.A.A., R.G. Woisky, G. Wiezel and M. Rodrigues,2005Cordia verbenacea V: Oral and topical anti-inflammatory activity, analgesic effect and fetus toxicity of a crude leaf extract.]]>12338344Smart, N.A. and T.T. Titus,201112410731080Xing, R., S. Liu, H. Yu, Y. Qin, X. Chen, K. Li and P. Li,201465383388