Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2015.50.60El-AnwarRehab F. WahmanLobna F. MelekS.T. 22015152Isotretinoin is the most effective anti-acne treatment but to some extent it has side effects. So, the aim of the present study was focused on the combined effect of isotretinoin treatment and hypothyroidism on cerebral monoamines in male albino rats. The animals were divided into four groups; control, hypothyroid, hypothyroid treated with isotretinoin and isotretinoin only treated. Hypothyroidism was induced by using 5 mg kg1 propylthiouracil for 30 days. Oral isotretinoin was given in olive oil 1.5 mg kg1 b.wt. equivalent to human therapeutic dose for 4 weeks. The withdrawal period is 2 weeks after drug stoppage. The concentration of epinephrine, nor epinephrine, dopamine and serotonin were estimated in different brain areas. Also, the serum level of free triiodothyronine and free thyroxin and thyroid stimulating hormone were measured to insure the hypothyroid state. Total body weight was recorded throughout the experimental period. Hypothyroid rats model exhibited a decrease of norepinephrine, dopamine and serotonin contents in most of the brain areas examined. Hypothyroid rats treated with isotretinoin exhibited elevated levels of neurotransmitter in most brain areas. isotretinoin treatment does not aggravate the monoamines dysfunction in hypothyroid rats.]]>Henley, W.N. and T.J. Koehnle,1997273644Allain, H., A.V. Masson, D. Bentue-Ferrer, P. Toulouse and F. Lecoz,199521915Arborelius, L., M.J. Owens, P.M. Plotsky and C.B. Nemeroff,1999160112Bahls, S.C. and G.A. de Carvalho,2004264048Bremner, J.D., K.D. Shearer and P.J. McCaffery,2012733750Bernal, J.,200225268288Bianco, A.C., D. Salvatore, B. Gereben, M.J. Berry and P.R. Larsen,2002233889Booij, L., A.J.W. van der Does and W.J. Riedel,20038951973Bradley, D.J., W.S. Young 3rd and C. Weinberger,19898672507254Braverman, L.E.,199642174178Bremner, J.D. and P. McCaffery,200832315331Cook, C.B., I. Kakucska, R.M. Lechan and R.J. Koenig,199213010771079Cattani, D., P.B. Goulart, V.L. de Liz Oliveira Cavalli, E. Winkelmann-Duarte and A.Q. dos Santos et al.,20133751426 D'Aquila, P.S., A.T. Peana, V. Carboni and G. Serra,200014347352DeGroot, L.J., P.R. Larsen, S. Refetoff and J.B. Stanbury,1984Dalgard, F., U. Gieler, J.O. Holm, E. Bjertness and S. Hauser,200859746751Dratman, M.B. and J.T. Gordon,19966639647Dratman, M.B., F.L. Crutchfield, Y. Futaesaku, M.E. Goldberger and M. Murray,1987125I] triiodothyronine in the rat brain: Evidence for neural localization and axonal transport derived from thaw-mount film autoradiography.]]>260392408Esposito, S., A.J. Prange Jr. and R.N. Golden,199733205217Ferguson, S.A., F.J. Cisneros, B.J. Gough and S.F. Ali,20054312891296Glass, C.K.,199415391407Hendrick, V., L. Altshuler and P. Whybrow,199821277292Howland, R.H.,199344633639Huang, C.,201014251260Jones, H., D. Blanc and W.J. Cunlife,1980210481049Kempermann, G., L. Wiskott and F.H. Gage,200414186191Kempermann, G., S. Jessberger, B. Steiner and G. Kronenberg,200427447452Krezel, W., N. Ghyselinck, T.A. Samad, V. Dupe, P. Kastner, E. Borrelli and P. Chambon,1998279863867Lane, M.A. and S.J. Bailey,200575275293Lavado-Autric, R., E. Auso, J.V. Garcia-Velasco, M.C. Arufe, F.E. del Rey, P. Berbel and G.M. de Escobar,200311110731082Le Dose, F., D. Debruyne, F. Albessard, L. Barre and G.L. Defer,200028205208Maden, M.,2000596573Maden, M.,20023843853Mangelsdorf, D.J., S.A. Kliewer, A. Katiznka, K. Umesono and R.M. Eans,19934899121Mano, T., H. Sakamoto, K. Fujita, M. Makino and H. Kakizawa et al.,19988353358Sweetman, S.C.,201137th Edn.,Pages: 4142Pages: 4142Mellstrom, B., J.R. Naranjo, A. Santos, A.M. Gonzalez and J. Bernal,1991513391350Mey, J. and P. Mccaffery,200410409421Midgley, J.E.M.,20014713531363De Escobar, G.M., M.J. Obregon and F.E. Del Rey,2004151U25U37O'Reilly, K., S.J. Bailey and M.A. Lane,2008233251258O'Reilly, K.C., J. Shumake, F. Gonzalez-Lima, M.A. Lane and S.J. Bailey,20063119191927Olson, C.R. and C.V. Mello,201054489495Paget, G.E. and J.M. Barners,19641964pp: 135-166pp: 135-166Peat, M.A. and J.W. Gibb,1983128275280Pochi, P.E., A.R. Shalita, J.S. Strauss, S.B. Webster and W.J. Cunliffe et al.,199124495500Pies, R.W.,199719344354Ruhe, H.G., N.S. Mason and A.H. Schene,200712331359Schemer, A.,19673rd Edn.,pp: 42-67pp: 42-67Schneider, B.F. and W.L. Golden,1987599103, 105-106Serakides, R., V.A. Nunes, C.M. Silva, A.F.C. Ribeiro, G.V. Serra, M.G. Gomes and N.M. Ocarino,200254473477, (In Portuguese)Sheline, Y.I., P.W. Wang, M.H. Gado, J.G. Csernansky and M.W. Vannier,19969339083913Silva, C.M., R. Serakides, T.S. Oliveira, N.M. Ocarino, E.F. Nascimento and V.A. Nunes,200456628639, (In Portuguese)Spear, L.P.,200024417463Stern, R.S.,199226931935Targum, S.D., R.D. Greenberg, R.L. Harmon, K. Kessler, A.J. Salerian and D.H. Fram,198445345346Tejani-Butt, S.M., J. Yang and A. Kaviani,19935710111018Vaccari, A.,1982829395Kontaxakis, V.P., D. Skourides, P. Ferentinos, B.J. Havaki-Kontaxaki and G.N. Papadimitriou,20092009Weinberger, C., C.C. Thompson, E.S. Ong, R. Lebo, D.J. Gruol and R.M. Evans,1986erb-A gene encodes a thyroid hormone receptor.]]>324641646Wenzel, K.W.,1981in vitro tests of thyroid function.]]>30717732Wysowski, D.K., M. Pitts and J. Beitz,200145515519Yen, P.M.,20018110971142Chang, Y.J., C.M. Hwu, C.C. Yeh, P.S. Wang and S.W. Wang,2014191117811195