Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2007.465.472Bauhinia variegata on Complete Freund`s Adjuvant Induced Arthritis in Rats]]>RajkapoorB. RavichandranV. GobinathM. AnbuJ. HarikrishnanN. SumithraM. SankariM. VenugopalR. SakthisekaranD. 5200725Effect of ethanol extract of Bauhinia variegata (EBV) was evaluated for antiarthritic activity on complete Freunds adjuvant (CFA) induced arthritis in rat. The EBV was administered orally at the dose level of 250 mg kg-1 for 15 days. The paw volume was measured at 3rd, 5th, 10th and 15th days. At the end of these 15 day, the animals were sacrificed and various biochemical parameters such as serum aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total cholesterol and triglycerides were estimated. Antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and lipid peroxide (LPO) in liver and kidney of normal, arthritic control and EBV treated rats were studied. Oral administration of EBV effectively inhibits rat paw edema volume. EBV significantly (p<0.01) altered the biochemical parameters which got affected in arthritic rats. There was a significant alteration in LPO, SOD, catalase and GPx levels when compared to arthritic control rats. Our finding showed a significant antiarthritic effect of EBV against CFA induced arthritis in rats.]]>Ali, M.S., I. Azhar and Z. Amtul,199970299304Allen, R.C., R.L. Stjernholm and R.H. Steele,197247679684Babior, B.M., R.S. Kipens and J.T. Curnutte,197352741744Besson, J.M. and G. Guilbaud,1988pp: 257pp: 257Blake, D.R., N.D. Hall, D.A. Terby, B. Halliwell and J.M.C. Gutteridge,198161483488Butler, S.H., F. Godefroy, J.M. Besson and J. Weil-Fugaza,1992187381Cai, X., H. Zhou, Y.F. Wong, Y. Xie and Z.Q. Liu et al.,2005337586594Cain, C.K., J.M. Franeis, M.A. Plone, D.F. Emerich and M.D. Lindner,199762199205Calvino, B., M.A. Crepon-Bernard and D. Le Bars,1987241129Chandrasekaran, S., S. Anilkumar and S. Jamuna,200250225227Clatworthy, A.L., P.A. Llich, G.A. Castro and E.T. Walters,199518458Clopaert, E.C., T. Meert, P. Witle and P. Schemitt,1982316775Devasagayam, T.P. and U. Tarachand,1987145134138Duret, S. and R.R. Paris,197711213216Fahim, A.T., A.A. Abd-El Fattah, A.M. Agha and Z.M. Gad,1995317379Greenwald, R.A. and W.N. Moy,198023455464Gupta, A.K., T.J. Vidyapati and J.S. Chauhan,1979Bauhinia variegata.]]>188586Gupta, A.K., T.J. Vidyapati and J.S. Chauhan,1980Bauhinia variegata.]]>38174176Gutteridge, J.M.C.,1986869119127Haris, E.D.,1954Hawk, P.B., B.L. Oser and W.H. Summerson,1954Heliovaara, M., P. Knekt, K. Aho, R.K. Aaran, G. Alfthan and A. Aromaa,1994535153Jovanoic, S.V. and M.G. Simic,2000899326334Kasama, T., K. Kobayashi, F. Sekine, M. Negishi, H. Ide, T. Takahashi and Y. Niwa,19884318871896Kind, P.R.N. and E.J. King,19547322326Kirtikar, K .R. and B.D. Basu,1993Vol. II,pp: 898-900pp: 898-900Krune, S.M. and L. Simon,198630263283Marklund, S.L., P.A. Kling, S. Nilsson and M. Ohmun,198747567570Marklund, S. and G. Marklund,197447469474Marylatha, R., T. Geetha and P. Varalakshmi,199831601606Nadkarni, A.K.,1996pp: 683pp: 683Newbould, B.B.,1963Mycobacterial adjuvant.]]>21127136Rainsford, K.D.,1982124452458Rajkapoor, B., B. Jayakar, R. Anandan and S. Kavimani,2003Bauhinia variegata Linn in rats.]]>3215217Rajkapoor, B., B. Jayakar and N. Murugesh,2003Bauhinia variegata on Dalton's ascitic lymphoma.]]>89107109Rajkapoor, B., B. Jayakar and N. Murugesh,2003Bauhinia variegata against Ehrlich ascites carcinoma induced mice.]]>41604647Rajkapoor, B., B. Jayakar, N. Murugesh and D. Sakthisekaran,2006Bauhinia variegata against N-nitrosodiethylamine induced liver tumors and human cancer cell lines.]]>104407409Recklies, A.D., A.R. Poole and S. Banerjee,20002nd Edn.,pp: 439-530pp: 439-530Reddy, M.V.B., M.K. Reddy, D. Gunasekar, C. Caux and B. Bodo,2003Bauhinia variegata.]]>64879882Reitman, S. and S. Frankel,1957285663Salin, M.L. and J.M. McCord,19755613191319Sinha, A.K.,197247389394De, S., B. Ravishankar and G.C. Bhausar,1994Paederia foetida.]]>433138Wybenga, D.R. and V. Pileggi,197016980984Yadava, R.N. and V.M.S. Reddy,20012) α-L-rhamnopyroanoside from Bauhinia variegate Linn.]]>3341346Yadava, R.N. and V.M. Reddy,2003Bauhinia variegata Linn.]]>17165169Rotruck, J.T., A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafeman and W.G. Hoekstra,1973179588590