Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2008.449.456Typhonium flagelliforme on Human T4-Lymphoblastoid Cell Line CEM-ss]]>MohanS. BustamamA. IbrahimS. S. Al-ZubairiA. AspollahM. 6200836Typhonium flagelliforme (Lodd.) Blume, commonly known as rodent tuber in Malaysia, is one of the widely used alternative medicines in cancer therapy by South East Asian population. Intake of this plant is common among patients with malignancies especially Leukaemia, breast and cervical cancer; however no data available regarding the possible direct effect of T. flagelliforme in these cancers. The purpose of the present study was to investigate the potential in vitro cytotoxic effect of leaves and tubers of T. flagelliforme extracts against human T4-lymphoblastoid cell line CEM-ss. Among the 8 extracts Dichloromethane and Ethyl acetate extracts of T. flagelliforme demonstrated significant anti proliferative effect with a marked level for both leaves (10.8 and 5.8 μg mL-1) and tuber (6.5 and 8.2 μg mL-1), against CEM-ss cells. Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating anti cancer activity, that requires further investigation.]]>Choo, C.Y., K.L. Chan, K. Takeya and H. Itokawa,2001Typhonium flagelliforme (Araceae).]]>15260262Choo, C.Y., K.L. Chan, T.W. Sam, Y. Hitotsuyanagi and K. Takeya,2001Typhonium flagelliforme (Araceace).]]>77129131Chen, S.X., C.J. Gohand and O.L. Kon,1997Typhonium flagelliforme.]]>63580583Choon, S.L., H.M.H. Rosemal, N.K. Nair, M.I.A. Majid and S.M. Mansor et al.,2008Typhonium flagelliforme inhibits cancer cell growth In vitro and induces apoptosis: An evaluation by the bioactivity guided approach.]]>1181420Dahanukar, S.A., R.A. Kulkarni and N.N. Rege,20003281118Dassanayake, M.D and F.R. Fosberg,19881st Edn.,pp: 65-67pp: 65-67Gorman, A., J. McCarthy, D. Finucane, W. Reville and T. Cotter,19961996pp: 1-20pp: 1-20Huang, P., G. Karagianis and P.G. Waterman,2004Typhonium flagelliforme.]]>27173175Jerome, A., Q. Angelique and G. Marc,2003Arum italicum (Araceae).]]>141205214Kamesaki, H.,1998682943Mosmann, T.,1983655563Neoh, C.K.,1992478688Suffness, M. and J.M. Pezzuto,19901990pp: 71-133pp: 71-133Umamaheswari, A. and N. Govindan,2007Hibiscus sabdariffa leaves on hepatocellular carcinoma cell line Hep 3B.]]>3100105Zhong, Z., G. Zhou, X. Chen and P. Huang,2001Typhonium flagelliforme.]]>24735738Jun, X.X., H.Q. Guo, P.Z. Cai., D.R. Dan and H.Z. Sheng,200721820826