Rongfen Dong
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
Shanshan Shen
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 100700, Beijing, China
Baojie Dong
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
Li Zhou
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
He Yang
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
Guang Zheng
School of Information Science-Engineering, Lanzhou University, 730000, Lanzhou, China
Hongtao Guo
Henan Province Traditional Chinese Medicine Hospital, 450002, Zhengzhou, China
Cheng Lu
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 100700, Beijing, China
Jinrong Zhang
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
Zhaoli Cui
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
Longsheng Zhang
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
Aiping Lu
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 100700, Beijing, China
Miao Jiang
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 100700, Beijing, China
Yaoxian Wang
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100007, Beijing, China
ABSTRACT
Cerebrovascular diseases which is called wind stoke in Chinese medicine, happened commonly and frequently in either the community or healthcare setting. Poststroke motor dysfunction and shortage of effective or curative treatments bring an enormous emotional and financial burden. Ischemic cerebrovascular (ICVD) disease is one of the three principal diseases causing people to death in which seconded only to heart disease and cancer. The pathophysiological role of platelets and coagulation is largely unclear. The currently approved drugs of treating or preventing ICVD have significant limitations. Chinese Herbal Medicine (CHM) has been an integral part of Traditional Chinese Medicine for thousands of years. Some chinese herbs were proved to have potential benefits on neural regeneration in cerebral ischemic injury. Many herbal formulations have been developed and used in the treatment of ICVD and were proved to be effective and safe. In this study, a novel text mining method was development to explore the treatment principles more intuitively. Networks of TCM patterns and CHMs which are most frequently used in ICVD treatment are built-up and analyzed, two major principles are explored: Promoting blood circulation to remove blood stasis with strengthening healthy qi. These findings might guide the clinicians in treatment of ischemic cerebrovascular.
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How to cite this article
Rongfen Dong, Shanshan Shen, Baojie Dong, Li Zhou, He Yang, Guang Zheng, Hongtao Guo, Cheng Lu, Jinrong Zhang, Zhaoli Cui, Longsheng Zhang, Aiping Lu, Miao Jiang and Yaoxian Wang, 2013. Basic Treatment Pinciples for Ischemic Cerebrovascular Disease with Chinese Herbal Medicine: An Application of Text Mining. Information Technology Journal, 12: 5221-5225.
DOI: 10.3923/itj.2013.5221.5225
URL: https://scialert.net/abstract/?doi=itj.2013.5221.5225
DOI: 10.3923/itj.2013.5221.5225
URL: https://scialert.net/abstract/?doi=itj.2013.5221.5225
REFERENCES
- Jiang, M., C. Zhang, G. Zheng, H. Guo and L. Li et al., 2012. Traditional Chinese medicine zheng in the era of evidence-based medicine: A literature analysis. Evidence-Based Complement Alternat. Med.
CrossRefDirect Link - Kraft, P., S.F. De-Meyer and C. Kleinschnitz, 2012. Next-generation antithrombotics in ischemic stroke: Preclinical perspective on bleeding-free antithrombosis. J. Cereb. Blood Flow Metab., 32: 1831-1840.
CrossRefPubMedDirect Link - Wang, H.W., K.T. Liou, Y.H. Wang, C.K. Lu and Y.L. Lin et al., 2011. Deciphering the neuroprotective mechanisms of Bu-Yang Huan-Wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J. Ethnopharmacol., 138: 22-33.
CrossRefPubMedDirect Link - Zheng, G., M. Jiang, X.J. He, J. Zhao and H.G. Guo et al., 2011. Discrete derivative: A data slicing algorithm for exploration of sharing biological networks between rheumatoid arthritis and coronary heart disease. BioData Min.
CrossRefDirect Link