Liang Fei
Department of Pharmacy, Xi�an Medical University, Xi�an 710021, People of Republic China
Yu Lili
Department of Pharmacy, Xi�an Medical University, Xi�an 710021, People of Republic China
Yao Lin
Department of Pharmacy, Xi�an Medical University, Xi�an 710021, People of Republic China
Zhang Jingshu
Department of Pharmacy, Xi�an Medical University, Xi�an 710021, People of Republic China
ABSTRACT
Poly (vinyl alcohol) microspheres used for biomedical filed have attracted much attention for they contained lots of hydroxyl groups and can be modified with multipurpose. While the reaction steps of traditional preparation methods were tedious and uncontrollable, so the new method called inverse suspension-chemical crosslinking method was adopt to prepare poly (vinyl alcohol) microspheres by using Polyvinyl Alcohol (PVA) as monomer, Glutaraldehyde (GA) as crosslinker and Span-60 as dispersant. Effects of various factors such as amount of dispersant, stirring rate, volume ratio of oil to water phase, amount of crosslinker and hydrochloric acid, on the sphericity and size of microspheres were examined. The experimental results showed that the crosslinked microspheres with smaller size and more uniform size distribution, excellent sphericity and controllable diameter can be successfully prepared. As the amount of dispersant is less than 0.16 g, the stirring rate is lower than 250 r min-1, the ratio of oil to water is less than 1:1 and amount of crosslinker is more than 2 mL, the microspheres can not be formed in the system. Via controlling the reaction conditions, the crosslinked microspheres with excellent sphericity and controllable particle diameter in the range of 100~200 μm can be gained.
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How to cite this article
Liang Fei, Yu Lili, Yao Lin and Zhang Jingshu, 2013. Preparation of Micron-sized Crosslinked Poly (Vinyl Alcohol) Microspheres via Inverse Suspension-chemical Crosslinking Method. Journal of Applied Sciences, 13: 2676-2681.
DOI: 10.3923/jas.2013.2676.2681
URL: https://scialert.net/abstract/?doi=jas.2013.2676.2681
DOI: 10.3923/jas.2013.2676.2681
URL: https://scialert.net/abstract/?doi=jas.2013.2676.2681
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