Analysis of Blood for Secnidazole in Female Volunteers by HPLC Method


	Journal of Biological Sciences
	Year: 2002 \| Volume: 2 \| Issue: 11 \| Page No.: 769-770 DOI: 10.3923/jbs.2002.769.770

Analysis of Blood for Secnidazole in Female Volunteers by HPLC Method

Suriya Bibi , Rakhshanda Nawaz , M. Nawaz , Muhammad Shahid and Sobia Qamar Kiani

Abstract: The biokinetics parameters were investigated following oral dose of 1g secnidazole in healthy female volunteers. The plasma samples were deproteinized by ZnSO₄ and NaOH analyzed by HPLC. The mean maximum concentration in plasma was found to be 23.08?0.8 after 2.5 h of drug administration. The area under curve (AUC) was 349.05 ± 20.9 h mg L^-1. The clearance and volume of distribution were 0.44 ± 0.37 L h^-1 and 11.09 ± 7.81 L respectively. The elimination half life was 13.86?0.92 h. The values for absorption rate constant and absorption half life were 2.97 ± 0.46 L h^-1 and 0.27?0.03 h. The maximum concentration 16.24 ± 0.48 mg L^-1 was achieved in 1.77 ± 0.16 h. These parameters showed that protein deproteinization method and analysis techniques are valid for the protein analysis of secnidazole.

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How to cite this article:

Suriya Bibi , Rakhshanda Nawaz , M. Nawaz , Muhammad Shahid and Sobia Qamar Kiani , 2002. Analysis of Blood for Secnidazole in Female Volunteers by HPLC Method . Journal of Biological Sciences, 2: 769-770.

DOI: 10.3923/jbs.2002.769.770

URL: https://scialert.net/abstract/?doi=jbs.2002.769.770

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