Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2007 | Volume: 10 | Issue: 22 | Page No.: 4036-4042
DOI: 10.3923/pjbs.2007.4036.4042
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Spasmolytic Effect of Petroselinum crispum (Parsley) on Rat’s Ileum at Different Calcium Chloride Concentrations
A.A. Moazedi, D.N. Mirzaie , S.M. Seyyednejad , M.R. Zadkarami and A. Amirzargar

Abstract:
Traditional herbal medicines such as Petroselinum crispum (Parsley) have been used for treatment of intestinal disorders in Iran. To date no pharmacological evidence for their effectiveness has been reported. The aim of this study was to examine the relaxant effect of hydroalcoholic extract of Petroselinum crispum on isolated adult male Wistar rat’s ileum contraction by KCl 60 (mM). The extract was prepared from parsley seed with 80% ethanol. A portion of ileum was removed and placed in an organ bath containing Tyrode solution (37° C, pH = 7.4) bubbled with air. From a resting tension of 1 g, isotonic Transducer and Harvard Universal Oscillograph were used for recording contraction of ileum after administration of 60 mM KCl. Various concentration of extract were added to the bath. This experiment showed that, the extract in a dose-dependent manner decreased the induced-KCl ileums contraction (n = 7, p<0.001). Also adding extract before influence of KCl, cause reduced effect of KCl (n = 7, p<0.001). In addition, the Tyrode solution without CaCl2 and high concentration of K+, various concentration of extract significantly (n = 7, p<0.001) decreased the CaCl2-induced contraction. Therefore, it seems that the relaxation effect of extract alcoholic parsley seed on the contraction of ileum is performed by blocking of voltage-gated calcium channels.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Ziziphus spina-christi, a Native Plant from Khuzestan, Iran, as a Potential Source for Discovery New Antimicrobial Agents
  •    Antibacterial Effect of Ethanolic and Methanolic Extracts of Plantago ovata and Oliveria decumbens Endemic in Iran Against Some Pathogenic Bacteria
How to cite this article:

A.A. Moazedi, D.N. Mirzaie , S.M. Seyyednejad , M.R. Zadkarami and A. Amirzargar , 2007. Spasmolytic Effect of Petroselinum crispum (Parsley) on Rat’s Ileum at Different Calcium Chloride Concentrations. Pakistan Journal of Biological Sciences, 10: 4036-4042.

DOI: 10.3923/pjbs.2007.4036.4042

URL: https://scialert.net/abstract/?doi=pjbs.2007.4036.4042

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom