
	Asian Journal of Animal and Veterinary Advances
	Year: 2012 \| Volume: 7 \| Issue: 9 \| Page No.: 898-903 DOI: 10.3923/ajava.2012.898.903

Differential Sensitivities of Three Strains of Drosophila melanogaster (Diptera: Drosophilidae) to Imipramine as an Antidepressant Drug

M.R. Fakoorziba, M.H. Eghbal and F. Eghbal

Abstract: In developing world, with progression in modernity and industrialization and synthesis of new chemicals and drugs, man, animal and their ecosystem are constantly threatened by wild range of chemical substances. Several of which are known to be mutagenic, carcinogenic and teratogenic. The antidepressant drugs like imipramine and paroxetine are long-term use administered to many patients and they can cause so many complications and side effects. So, the differential sensitivity of three strains of Drosophila melanogaster for imipramine hydrochloride, an antidepressant drug has been tested by larval feeding. Wheat cream agar medium as normal food medium was used for breeding of Drosophila flies. LC₅₀ of imipramine was estimated by the larval feeding method and sub lethal concentrations of imipramine were selected. The effect of drug on viability, rate of development and sex ratio was analyzed. The results revealed that all three concentrations could reduce viability and significantly delay development. Among the three strains, Oregan-K, the wild type was found to be the most resistant. Sex ratio deviation was significant in concentration of 1 and 2 g L^-1 of imipramine in Oregan-K but in two mutant strains the deviation was insignificant.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Molecular Analysis for Nitrogenous Fertilizers Effect on Drosophila melanogaster Boule Gene

•	Insecticidal Activities of Averrhoa carambola on Drosophila melanogaster and Syntermes grandis

•	The Effect of Paroxetine, A Selective Serotonin Reuptake Inhibitor, on Blood Glucose Levels in Mice

•	A Method to Rapidly Identify to What Species Unknown Animals are Closely Related

How to cite this article:

M.R. Fakoorziba, M.H. Eghbal and F. Eghbal, 2012. Differential Sensitivities of Three Strains of Drosophila melanogaster (Diptera: Drosophilidae) to Imipramine as an Antidepressant Drug. Asian Journal of Animal and Veterinary Advances, 7: 898-903.

DOI: 10.3923/ajava.2012.898.903

URL: https://scialert.net/abstract/?doi=ajava.2012.898.903

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar

Science Alert