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| Acute Toxicity Study and Phytochemical Screening of Selected Herbal Aqueous Extract in Broiler Chickens |
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S.R. Hashemi,
I. Zulkifli,
M. Hair Bejo,
A. Farida and M.N. Somchit |
Abstract:
In order to collect ethnobotanical information about
growth and health promoter plants as feed additive in broiler chickens,
five medicinal plants Euphorbia hirta, Solanum torvum,
Zingiber officinale, Curcuma longa and Zingiber zerumbet
used by traditional medical practitioners for the treatment of several
ailments of microbial and non-microbial origins were investigated for
phytochemical screening and acute toxicity study. A total of 30 female
broiler chicks were obtained. At 21 days of age, the chicks were allocated
at random into six groups. Five chickens were assigned at random to each
treatment in five replicates and kept in 30 cages (one chickens per cage)
till five weeks of age. Five groups were administered a single oral dose
of 2,000 mg kg-1 b.wt. while 5 mL distilled water was given
to the control group of birds as placebo. Phytochemical screening study
showed that plant contained volatile oils, tannins, alkaloids, saponins,
flavonoids. Alkaloids and steroids were only found in the aqueous extract
of Euphorbia hirta. Tissues were harvested and processed for photomicrographic
examinations. Macro and microscopic observations indicated no alteration
in liver and kidneys of the treated birds with 2000 mg kg-1
of selected herbal plants extract. In the hematological study, a highly
significant decrease was observed in AST, ALT, ALP level of broiler group
receiving the aqueous extract of E. hirta 14 after of administration.
Acute toxicity study indicated that water suspensions of selected herbal
aqueous extract are not toxic when administered by the oral route to experimental
birds at 2000 mg kg-1 b.wt. In conclusion, the results obtained
in the present study are in agreement to a certain degree with the traditional
uses of the plants estimated as prophylaxis against various diseases and
promote of health.
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How to cite this article:
S.R. Hashemi, I. Zulkifli, M. Hair Bejo, A. Farida and M.N. Somchit, 2008. Acute Toxicity Study and Phytochemical Screening of Selected Herbal Aqueous Extract in Broiler Chickens. International Journal of Pharmacology, 4: 352-360.
DOI: 10.3923/ijp.2008.352.360
URL: https://scialert.net/abstract/?doi=ijp.2008.352.360
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