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Articles by Pilanthana Lertsatitthanakorn
Total Records ( 2 ) for Pilanthana Lertsatitthanakorn
  Pilanthana Lertsatitthanakorn and Bhuddhipong Satayavongthip
  Skin bacterial flora, namely Staphylococcus epidermidis, are able to metabolise sweat that hence leads to foot odor. Moreover, Bacillus subtilis was found in the plantar skin of subjects possessing strong foot odor. The synthetic antibacterial agent generally used in various foot deodorant formulations is triclosan which tends to cause bacterial tolerance. To avoid that shortcoming, researchers in this study developed a natural foot deodorant gel from essential oils. Previous research of our group revealed that cinnamon oil showed a higher antibacterial activity against S. epidermidis than the essential oils obtained from kaffir lime, lemongrass, sweet basil, galanga and ginger. In the present study, the susceptibility of B. subtilis to the mentioned essential oils was determined and the results showed that cinnamon oil possessed the highest activity. Foot deodorant gel containing cinnamon oil was formulated and studied for its biological stability for 90 days at accelerated conditions. The lethal effect of the cinnamon oil gel exposed to B. subtilis for 1 h, was studied at day 0, 15, 30, 60 and 90. It was found that on all sampling days, cinnamon oil gel could decrease by at least 90% the initial bacterial population after 1 h of contact time. In conclusion, cinnamon oil foot deodorant gel demonstrated a good ability to decrease the bacteria involved in strong foot odor. The cinnamon oil foot deodorant gel might be an alternative cosmetic for people who have strong foot odor.
  Pawitra Pulbutr , Wanida Caichompoo , Pilanthana Lertsatitthanakorn , Methin Phadungkit and Sakulrat Rattanakiat
  The essential oil from the fruits of Amomum uliginosum K.D. Koenig has been commonly used in Thai herbal formula for the treatment of gastrointestinal diseases. However, the biological activity of the essential oil obtained from A. uliginosum fruits has never been reported. This study was aimed to investigate the pharmacological activities and cytotoxic effect of the essential oil derived from the fruit of A. uliginosum. The essential oil derived from the authentic fruits and the commercial fruits were prepared by distillation with the yield of 2.90±0.00 and 2.90±0.30% v/w, respectively. The chemical constituents of the essential oil were analyzed by GC-MS. Twenty one and 13 chemical compounds were found in the essential oil derived from the authentic and commercial fruits, respectively. The major chemical compound presented in the essential oil from both sources was bornyl acetate. The essential oil exhibited an antibacterial activity against gastrointestinal disorder-related bacteria with the lowest MIC of 75 μL mL-1 against E. coli O157:H7 DMST 12743 and S. aureus DMST 8013. The essential oil exerted the cytotoxic effect on 3T3 fibroblasts with the IC50 of 0.0725±0.0045 μL mL-1. The strong antimutagenic effect in Salmonella typhimurium TA 98 was found at the concentration of 3.75 mL plate-1. These results scientifically confirmed the use of the essential oil derived from A. uliginosum for the medicinal purposes. Additionally, its potential application for the use as cancer chemoprevention is also indicated from this study.
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