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The infection process of Sclerotinia sclerotiorum (Lib.) de Bary, a necrotrophic plant pathogen with more than 600 host plants, causing several disease symptoms such as cottony rot, watery soft rot, stem rot, white mould etc in a wide range of host plants remains sketchy. Specifically, virulence factors produced during host invasion require a special compilation to provide various researchers with this critical knowledge. This review discussed the virulence factors produced by S. sclerotiorum during plant invasion and colonization. The discussion was organized under the topics of S. sclerotiorum necrotrophic lifestyle, weaponry and the molecular aspect of its pathogenicity, zooming-in on the roles of its virulence factors (Cell wall degrading enzymes, effectors and oxalic acid) during pathogenicity.