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Articles by Xin Xu
Total Records ( 5 ) for Xin Xu
  Xin Xu and Manman Peng
  With the shift towards Chip Multiprocessors (CMPs), load imbalance between the different CPU due to causes not controlled by the application developer, resulting in significant performance degradation and waste of CPU time. Although there are many techniques to address load imbalance at run-time, as it happens, these techniques may not be particularly effective when the cause of the imbalance is due to the performance sensitivity of the parallel threads when accessing a shared cache. To this end, we present a novel run-time mechanism, using criticality prediction to guide cache space allocate, with minimal hardware, that automatically tries to balance parallel applications using dynamic cache allocation. The mechanism detects which thread is critical and reduces imbalance by assigning more cache space to the slowest threads. This experiment on a detailed microprocessor simulator with the Computer Vision and Data Mining applications reveal that this scheme can improve performance from 1-6%. Fine-grained temporal control is particularly important for parallel applications which are expected to be increasingly prevalent in years to come.
  Dong Gao , Xin Xu and Xin Ma
  In recent years, simulation technology has been widely used for operator training, experiments and research of control strategy in chemical process. However it is difficult to evaluate the results of operator training, experiments and research. A general automatic scoring framework is proposed for chemical simulation process. In the framework, chemical simulation process is divided into five aspects: Operation, quality, safety, consumption, production. In the aspects, the results of operator training, experiments and research can be evaluated and scored automatically. Basing on the framework, an automatic scoring system is designed and developed. The system is developed as a Dynamic Link Library (DLL) and can supply automatic scoring for various chemical simulation systems.
  Wei Fen Li , Imran Rashid Rajput , Xin Xu , Ya Li Li , Jian Lei , Qin Huang and Min Qi Wang
  The study was conducted to evaluate the effects of probiotic supplementation (Bacillus subtilis) in diet on performance, blood properties and microflora of Shaoxing duck. A population of 200 laying ducks (160 days old) was divided into two groups each having five replications. The control (T0) were fed on basal diet while T1 with Bacillus subtilis 1 x 108 CFU/kg in addition to basal diet for thirty five days. The results showed that for T1 group, the egg laying rate increased (3.79%) significantly, while a decrease of about 12.60%, 23.52% and 40.14% was observed in egg triglyceride, total cholesterol and malondialdehyde, respectively. However, the blood glucose content and alkaline phosphatase activity increased by 15.13% and 53.41%, significantly. Moreover, there was a decrease of blood cholesterol, uric acid and ammonia in T1 by 28.86%, 22.39% and 62.5%, respectively. As compared to T0, T1 showed a significant increased in the amount of caecal microflora, i.e. general aerobic bacteria (18.68%) and Lactobacillus (9.92%). In conclusion, supplementation of Bacillus subtilis in diets had significant effects on some aspects of egg composition, biochemical properties of blood and few microflora of Shaoxing ducks.
  Dong Gao , Xin Xu and Xin Ma
  In recent years, chemical simulation systems have been widely used in operator training, chemical parameter optimization and implement of control strategy. However, it is difficult to evaluate the result of operator training, chemical parameter optimization, implement of control strategy objectively and comprehensively. In the study, an ontology-based automatic scoring framework is proposed for chemical simulation system. A scoring ontology is built in the framework for sharing and reuse of knowledge. Basing on the scoring ontology, the framework can supply evaluation of operation, performance of control loops, safety, production and consumption in the simulation system. The case study proved the efficiency, objectiveness, comprehensiveness of the framework.
  Xin Xu , Sivaraja Vaithiyalingam , Gloria G. Glick , Daniel A. Mordes , Walter J. Chazin and David Cortez
  ATR kinase activation requires the recruitment of the ATR-ATRIP and RAD9-HUS1-RAD1 (9-1-1) checkpoint complexes to sites of DNA damage or replication stress. Replication protein A (RPA) bound to single-stranded DNA is at least part of the molecular recognition element that recruits these checkpoint complexes. We have found that the basic cleft of the RPA70 N-terminal oligonucleotide-oligosaccharide fold (OB-fold) domain is a key determinant of checkpoint activation. This protein-protein interaction surface is able to bind several checkpoint proteins, including ATRIP, RAD9, and MRE11. RAD9 binding to RPA is mediated by an acidic peptide within the C-terminal RAD9 tail that has sequence similarity to the primary RPA-binding surface in the checkpoint recruitment domain (CRD) of ATRIP. Mutation of the RAD9 CRD impairs its localization to sites of DNA damage or replication stress without perturbing its ability to form the 9-1-1 complex or bind the ATR activator TopBP1. Disruption of the RAD9-RPA interaction also impairs ATR signaling to CHK1 and causes hypersensitivity to both DNA damage and replication stress. Thus, the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling.
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