B. C. Saha
Aftab Bohumukhi Farms Ltd., Kishoregonj
P. M. Das
Bangladesh Agricultural University, Mymensingh, Bangladesh
S. Das
Chittagong Veterinary and Animal Sciences University, Chittagong, Bangladesh
ABSTRACT
A zinc-selenium complex (Selcon®) was evaluated for the prevention of IBDV infection in broilers. Chicks were reared in relative isolation with optimum temperature, water and feeds. They were divided into 4 different groups named A1, B1, A2 and B2; having 3 replications each. Among them Groups A1 and B1 were uninfected group of which Group B1 was supplemented with Selcon®. The rest 2 groups (A2 and B2) were Infected (challenge) group of which Group B2 were supplemented with Selcon®as a preventive measure. At 28 days of age all the birds of challenge Groups (A2 and B2) were inoculated with field homogenates of Infectious Bursal Disease (IBD) virus. The birds were observed for clinical signs, morbidity and mortality at every 6 h interval upto 10 days post infection. Three birds from each of the four groups of three replications were sacrificed at 0, 3 and 6 days post infection and bursa/body weight ratio was determined. Part of bursal tissues were fixed in formalin and processed for bursal lesion scoring along with spleen, thymus, liver and kidney tissues by histopathological study. Selcon® treated IBDV challenged birds of Group B2 revealed 44.44% overall cumulative morbidity and 2.22% overall cumulative mortality, while Selcon® untreated IBDV challenged birds of Group A2 revealed 60.00% overall cumulative morbidity and 11.11% overall cumulative mortality. Results also showed significant difference (p>0.05) in bursa/body weight ratio between Selcon® treated and untreated groups, that overall bursa/body weight ratio in birds of Group B2 was highest (1.30"0.44) and lowest (1.23"0.42) in those of Group A2 had at 6 days post infection. The bursal lesion scores of Group B2 were lower than Group A2. There was no significant variation among the histopathological lesions of spleen, thymus, liver and kidneys of different groups. It may be concluded that supplementation of Selcon® to broiler diets as a preventive measure provides a satisfactory level of protection against morbidity and mortality in IBD.
PDF References
How to cite this article
B. C. Saha, P. M. Das and S. Das, 2010. Effect of Zinc-selenium Complex (Selcon7) Supplementation in Broiler in Prevention of Infectious Bursal Disease. International Journal of Poultry Science, 9: 1069-1075.
DOI: 10.3923/ijps.2010.1069.1075
URL: https://scialert.net/abstract/?doi=ijps.2010.1069.1075
DOI: 10.3923/ijps.2010.1069.1075
URL: https://scialert.net/abstract/?doi=ijps.2010.1069.1075
REFERENCES
- Arthur, J.R., R.C. McKenzie and G.J. Beckett, 2003. Selenium in the immune system. J. Nutr., 133: 1457S-1459S.
CrossRefDirect Link - Baum, M.K., G. Shor-Posner and A. Campa, 2000. Zinc status in human immunodeficiency virus infection. J. Nutr., 130: 1421S-1423S.
Direct Link - Cheville, N.F., 1967. Studies on the pathogenesis of Gumboro disease in the bursa of fabricius, spleen and thymus of the chicken. Am. J. Pathol., 51: 527-551.
Direct Link - Cosgrove, A.S., 1962. An apparently new disease of chickens-avian nephrosis. Avian Dis., 6: 385-389.
Direct Link - Ferencik, M. and L. Ebringer, 2003. Modulatory effects of selenium and zinc on the immune system. Folia Microbiol., 48: 417-426.
CrossRef - Gomez, K.A. and A.A. Gomez, 1984. Statistical Procedures for Agricultural Research. 2nd Edn., John Wiley and Sons, Hoboken, New Jersey, ISBN: 9780471870920, Pages: 704.
Direct Link - Levander, O.A., 1997. Nutrition and newly emerging viral diseases: An overview. J. Nutr., 127: 948-950.
PubMed - Prasad, A.S., F.W. Beck, S.M. Grabowski, J. Kaplan and R.H. Mathog, 1997. Zinc deficiency: Changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proc. Assoc. Am. Physicians., 109: 68-77.
PubMed - Raue, R., M.R. Islam, M.N. Islam, K.M. Islam, S.C. Badhy, P.M. Das and H. Muller, 2004. Reversion of molecular engineered, partially attenuated, very virulent infectious bursal disease virus during infection of commercial chickens. Avian Pathol., 33: 181-189.
PubMed - Rossels, A.G., P. Villegas, P.D. Lukert, O.J. Fletcher, J. Brown, M.A. Mohammed and J. Brown, 1989. Pathogenicity of recent isolate of infectious bursal disease virus in specific pathogen free chickens: Protection conferred by an intermediate vaccine stain. Avian Dis., 33: 729-734.
Direct Link - Solomons, N.W., 1998. Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutr. Rev., 56: 27-28.
CrossRef - Tsukamoto, K., T. Matsumura, M. Mase and K. Imai, 1995. A highly sensitive, broad spectrum infectivity assay for infectious bursal disease virus. Avian Dis., 39: 575-586.
PubMed