I. M. Alhazza
Department of Zoology, College of Science, King Saud University,
P.O. Box 2455, Riyadh 11451, Saudi Arabia
ABSTRACT
The present study was conducted to investigate the possible effect of Selenium (Sel) against Cadmium (Cd) toxicity on hormones and gonads of male rats. Male rats were divided into three groups. First group served as control, second group administrated s.c. cadmium chloride (2.5 mg kg -1) and third group injected s.c. with Sel (0.35 mg kg -1) and Cd. In the last group, the animals were treated with Sel one hour before Cd treatment. Blood samples were collected and eight animals were sacrificed after two, four, six and eight weeks. Plasma testosterone, FSH and LH were assayed using enzyme immunoassay method. The sperm quality was evaluated. Cd in the testes was determined using atomic absorption. The weights of body, testes and accessory sex organs were recorded. The treatment of the rats with Cd results in a significant decrease of testosterone, LH, sperm motility (%), body gain and weights of testes, epididymis, vas deference, seminal vesicle and prostate gland. On the other hand, the sperm abnormalities and FSH concentration increased significantly in Cd treated rats. Cd content in the testes of second group and third group increased in a time-related fashion. Cd concentration in the testes of rats treated with Cd and Sel was less than that of rats injected with Cd alone. Sel was found to reduce the deleterious effects of Cd.
PDF References Citation
How to cite this article
I. M. Alhazza, 2005. Effect of Selenium on Cadmium Induced Gonadotoxicity in Male Rats. Journal of Biological Sciences, 5: 243-249.
DOI: 10.3923/jbs.2005.243.249
URL: https://scialert.net/abstract/?doi=jbs.2005.243.249
DOI: 10.3923/jbs.2005.243.249
URL: https://scialert.net/abstract/?doi=jbs.2005.243.249
REFERENCES
- Mahaffey, K.R., S.G. Capar, B.C. Gladen and B.A. Fowler, 1981. Concurrent exposure to lead, cadmium and arsenic. Effects on toxicity and tissue metal concentrations in the rat. J. Lab. Clin. Med., 98: 463-481.
PubMed - Chow, C.K. and C.B. Hong, 2002. Dietary vitamin E and selenium and toxicity of nitrite and nitrate. Toxicol., 180: 195-207.
CrossRefDirect Link - Frisk, P., A. Yaqob and U. Lindh, 2002. Indications of selenium protection against cadmium toxicity in cultured K-562 cells. Sci. Total Environ., 296: 189-197.
Direct Link - Patra, R.C., D. Swarup, S.K. Senapati, 1999. Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic, renal and testicular tissue of rats. Vet. Hum. Toxicol., 41: 65-66.
Direct Link - Stajn, A., R.V. Zikic, B. Ognjanovic, Z.S. Saicic, S.Z. Pavlovic, M.M. Kostic and V.M. Petrovic, 1997. Effect of cadmium and selenium on the antioxidant defense system in rat kidneys. Comp. Biochem. Physiol. Part C: Pharmacol. Toxicol. Endocrinol., 117: 167-172.
CrossRefDirect Link - Laskey, J.W., G.H. Rehnberg, S.C. Laws and J.F. Hein, 1984. Reproductive effects of low acute doses of cadmium chloride in adult male rats. Toxicol. Applied Pharmcol., 73: 250-255.
CrossRefDirect Link - Lewin, M.H., J.R. Arthur, R.A. Riemersma, F. Nicol and S.W. Walker et al., 2002. Selenium supplementation acting through the induction of the thioredoxin reductase and glutathione peroxidase protects the human endothelial cell line EAhy926 from damage by lipid hydroperoxides. Biochem. Biophys. Acta, 1593: 85-92.