International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2016.28.35Ziziphora tenuior L. Essential Oil Against Multidrug-resistant Acinetobacter baumannii]]>CelikCem TutarUgur KaramanIsa HepokurCeylan AtasMehmet 12016121Acinetobacter baumannii is one of the most important gram-negative microorganisms which lead to opportunistic hospital-acquired infections. A great part of the infections it causes is produced by strain resistant to all the antibiotics used. In our study, the Essential Oil (EO) of the Ziziphora tenuior L. antimicrobial and antibiofilm effects on multidrug resistant (MDR) A. baumannii isolates were researched. In addition, antioxidant, cytotoxic activity and chemical composition of EO were investigated. As a result of the gas chromatography-mass spectrometry (GC-MS) analysis of the Z. tenuior EO pulegone was found as the major component by 74.37%. It was observed when the antimicrobial activity of the EO was examined that it had >30 mm disc diffusion values. Minimal Inhibition Concentration (MIC) values were found between 0.6-1.25 μL mL1 and Minimal Bactericidal Concentration (MBC) values were found between 2.5-5 μL mL1. Minimal biofilm inhibition concentration (MBIC) values of the EO were found as 0.3-1.25 μL mL1 and Minimal Biofilm Eradication Concentration (MBEC) value as 5-10 μL mL1. It was seen that the MIC value damaged the biofilm formations constituted by the A . baumannii strains by 51-84%. At 25, 12.5 and 6.25% EO concentrations, no cytotoxic appeared for the fibroblast cells in terms of the cytotoxic activities (p>0.05). Findings that were obtained in our study seem promising for the development of phytotherapeutic agents that could be used in the treatment of the MDR A. baumannii infections.]]>Aksit, H., I. Demirtas, I. Telci and G. Tarimcilar,2013Mentha longifolia (L.) Hudson subsp. typhoides (Briq.) Harley var. typhoides from Turkey.]]>25430437Antunes, L.C.S., P. Visca and K.J. Towner,2014Acinetobacter baumannii: Evolution of a global pathogen.]]>71292301Ceri, H., M.E. Olson, C. Stremick, R.R. Read, D. Morck and A. Buret,19993717711776Chaieb, K., B. Kouidhi, H. Jrah, K. Mahdouani and A. Bakhrouf,2011Nigella sativa and its potency to prevent bacteria biofilm formation.]]>2011CLSI.,20142014Dakah, A., S. Zaid, M. Suleiman, S. Abbas and M. Wink,2014In vitro propagation of the medicinal plant Ziziphora tenuior L. and evaluation of its antioxidant activity.]]>21317323Davies, J. and D. Davies,201074417433Dhingra, A.K., B. Chopra, S. Bhardwaj and K.L. Dhar,201141921Gholivand, M.B., M. Piryaei and S.M. Maassoumi,2014Ziziphora tenuoir methanolic extracts and comparison of the essential oil in two stages of growth.]]>12505511Gillings, M.R., M.P. Holley and H.W. Stokes,2009qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms.]]>296282288Golfakhrabadi, F., F. Yousefbeyk, T. Mirnezami, P. Laghaei, M. Hajimahmoodi and M. Khanavi,2015Teucrium hyrcanicum.]]>71519Heydari, S. and F. Eftekhar,2015Pseudomonas aeruginosa.]]>2015Howard, A., M. O'Donoghue, A. Feeney and R.D. Sleator,2012Acinetobacter baumannii: An emerging opportunistic pathogen.]]>3243250Kaya, A., F. Satil, T. Dirmenci and S. Selvi,2013Ziziphora (Lamiaceae).]]>31270277Kim, Y., I.K. Bae, S.H. Jeong, D. Yong and K. Lee,2015In vivo selection of pan-drug resistant Acinetobacter baumannii during antibiotic treatment.]]>56928934Langeveld, W.T., E.J.A. Veldhuizen and S.A. Burt,2014407694Longo, F., C. Vuotto and G. Donelli,2014Acinetobacter baumannii.]]>37119127Macia, M.D., E. Rojo-Molinero and A. Oliver,201420981990Mahboubi, A., M. Kamalinejad, A.M. Ayatollahi and M. Babaeian,2014Labiatae against four foodborne and some other bacteria.]]>13559566Mahboubi, M., N. Kazempour and M. Taghizadeh,2014Acinetobacter baumannii.]]>36513519Marotti, M., R. Piccaglia, E. Giovanelli, S.G. Deans and E. Eaglesham,1994Mentha x Piperita L.) essential oil composition and its biological activity.]]>9125129Ozturk, S. and S. Ercisli,2007Ziziphora clinopodioides.]]>18535540Penesyan, A., M. Gillings and I.T. Paulsen,20152052865298Perumal, S.,2013Euphorbia hirta L. against clinical isolates and standard strains.]]>2013Pirbalouti, A.G., A. Amirkhosravi, F. Bordbar and B. Hamedi,2013Ziziphora tenuior as a potential source of pulegone.]]>24234239Polat, Z.A., J. Walochnik, A. Obwaller, A. Vural, A. Dursun and M.K. Arici,2014Acanthamoeba keratitis.]]>42151158Sarac, N. and A. Ugur,2009in vitro antimicrobial activities of the essential oils of some Lamiaceae species from Turkey.]]>12902907Towner, K.J.,200973355363Yap, P.S.X., B.C. Yiap, H.C. Ping and S.H.E. Lim,20148614Zarrilli, R., S. Pournaras, M. Giannouli and A. Tsakris,2013Acinetobacter baumannii clonal lineages.]]>411119