Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2020.191.195Bridelia ferruginea (Euphorbiaceae) on Wistar Rat]]>Délagnon IrénéeKueviakoe Messanh Komlan MawubédjroDossou-Yovo AboudoulatifDiallo AhoefaVovor KwashieEklu-Gadegbeku 52020205Background and Objective:Bridelia ferruginea is a widely plant used in Togo for traditional healing of many diseases such as sickle cell anemia, bladder disorders, malaria, rheumatism and diabetes. Many parts of the plant are then, used for this purpose. This study aims to investigate the subacute toxicity of the stem bark of Bridelia ferruginea by repeated oral dose of 28 days on Wistar rats. Materials and Methods: Three groups of 8 rats were used to evaluate the subacute toxicity of B. ferruginea stem bark extract. The first group served as control and received distilled water and the two other groups received, respectively 500 and 1000 mg kg1 of extract. The solutions were administrated orally to rats for 28 days and each animal received 10 mL kg1 of solution. At the end of the study, hematological and biochemical parameters were recorded as well as the histological study of some organs. Results: The 28 day repeated oral administration of B. ferruginea stem bark extract at 500 and 1000 mg kg1 did not induce significant changes in hematological and biochemical parameters except for creatine kinase when compared to the control group. No architectural changes were observed on organ histological data in all groups. Conclusion: The hydroalcoholic extract of B. ferruginea stem bark is relatively safe for oral administration in Wistar rats as no toxic effect was observed during the 28 days of administration.]]>Kale, O.E., O. Awodele and A.J. Akindele,2019Acridocarpus smeathmannii (DC.) Guill. & Perr. root in Wistar rats.]]>6161175Adeneye, A.A.,20142014pp: 99-133pp: 99-133Alowanou, G.G., A.P. Olounlade, E.V.B. Azando, V.F.G.N. Dedehou, F.D. Daga and M. Hounzangbe-adote,2015Bridelia ferruginea, Combretum glutinosum and Mitragina inermis plants used in zootherapeutic remedies in West Africa: Historical origins, current uses and implications for conservation.]]>8780038014Bakoma, B., S. Sanvee, K. Metowogo, Y. Potchoo, K. Eklu Gadegbeku, K. Aklikokou and M. Gbeassor, 201911141145Irobi, O.N., M. Moo-Young, W.A. Anderson and S.O. Darambba,1994Bridelia ferruginea (Euphorbiaceae).]]>43185190Adetutu, A., W.A. Morgan and O. Corcoran,2011in vitro evaluation of wound-healing plants used in South-western Nigeria.]]>1375056Mbah, C.C., G.C. Akuodor, N.A. Anyalewechi, T.C. Iwuanyanwu and U.A. Osunkwo,2012In vivo antiplasmodial activities of aqueous extract of Bridelia ferruginea stem bark against Plasmodium berghei berghei in mice.]]>50188194Ngueyem, T.A., G. Brusotti, G. Caccialanza and P.V. Finzi,2009Bridelia: A phytochemical and ethnopharmacological review.]]>124339349Fabiyi, O.A., O. Atolani, O.S. Adeyemi and G.A. Olatunji,2012Bridelia ferruginea leaves.]]>2S981S984Gupta, V.K. and S.K. Sharma,20065326334Mpiana, P.T., D.S.T. Tshibangu, O.M. Shetonde and K.N. Ngbolua,2007In vitro antidrepanocytary actvity (anti-sickle cell anemia) of some congolese plants.]]>14192195Bakoma, B., B. Berke, K. Eklu-Gadegbeku, A. Agbonon and K. Aklikokou et al.,2013Bridelia ferruginea Benth root bark in male rodent animals.]]>52176179Harborne, J.B.,19842nd Edn.,Pages: 288Pages: 288Njoku, V.O. and C. Obi,20093228233Olson, H., G. Betton, D. Robinson, K. Thomas and A. Monro et al.,2000325667Awodele, O., K.I. Amagon, J. Agbo and M.N.V. Prasad,2015Bridelia ferruginea (Euphorbiaceae) in rodents.]]>88998Olarewaju, O.I., O.I. Oloyede, O.A. Ojo and S.A. Onikanni, 2013Bridelia ferruginea stem bark on some haematological parameters of albino rats. ]]>17075Owoseni, A.A., T.A. Ayanbamiji, Y.O. Ajayi and I.B. Ewegbenro,2010Bridelia ferruginea.]]>910311036