Kidney Research Journal1819-33742154-3836Academic Journals Inc.10.3923/krj.2012.1.11MohsenM.A. KarimS.A. Abdel SultanW.A. AbbasT.M. 1201221Kidney involvement in systemic lupus erythematosus (SLE) is life threatening
complication. Urinary N-acetyl-beta-D glucosaminidase (uNAG) activity has emerged
as potentially useful early marker of renal tubular injury. The uNAG excretion
was investigated in 72 SLE patients to assess tubular dysfunction and determine
its relationship with disease activity and pathological classes of lupus nephritis
(LN). SLE patients were divided into two groups: 41 patients with LN and 31
patients without evidence of nephritis. Disease activity was assessed by SLEDAI.
Renal disease activity was measured by the Systemic Lupus International Collaborating
Clinics Renal Activity Score. uNAG levels were measured using colorimetric assay
kit and compared to 25 healthy controls. Renal biopsies were performed for LN
patients and glomerular lesions were classified according to WHO criteria. Severity
of tubulointerstitial involvement was also assessed. The uNAG activity was significantly
higher in LN patients than in lupus non nephritis patients and healthy controls
(both p<0.001). Tubular dysfunction with elevated uNAG was present in 6 lupus
non-nephritis patients with no evidence of glomerular disease. There was positive
significant relation between uNAG and proteinuria (p<0.005) and renal activity
score (p<0.001) in LN patients. Conversely, uNAG excretion was not significantly
correlated with SLEDAI, WHO classes of nephritis and tubulointerstitial index.
In conclusion, increased uNAG activity in lupus non-nephritis patients may predict
the development of LN prior to the onset of proteinuria. Increased uNAG activity
parallels the degree of renal disease activity in LN patients and is probably
more sensitive indicator of tubulointerstitial disease.]]>Abbas, D., H. Darweesh and A. Rashad,2010321927Bardi, E., A.V. Olah, K. Bartyik, E. Endreffy, C. Jenei, J. Kappelmayer and C. Kiss,200443668673Bazzi, C., C. Petrini, V. Rizza, G. Arrigo, P. Napodano, M. Paparella and G. D'Amico,20021718901896Bombardier, C., D. Gladman, B. Urowitz, D. Caron and C.H. Chang,199235630640Bosomworth, M.P., S.R. Aparicio and A.W. Hay,199914620626Cook, M.E., J.D. Wallin, V.D. Thakur, P.J. Kadowitz and D.B. McNamara et al.,19972411371144D'Amico, G.,199983289295D'Amico, G. and C. Bazzi,200312639643De Carvalho, J.F., A.P. do Nascimento, L.A. Testagrossa, R.T. Barros and E. Bonfa,20103013111315Delektorskaya, L., T. Janushkevich and D. Okunev,199031375379Erdener, D., K. Aksu, I. Bicer, E. Doganavsargil and F.Z. Kutay,200519172176Gatua, W.K., J.N. Makumi, E.M. Njagi, C.S. Kigondu, S.O. Mcligeyo and S.K. Waithaka,201138490Gluhovschi, C., S. Velciov, A. Kaycsa, G. Gluhovschi and L. Petrica et al.,201234163169Gressner, A.M. and P. Roebruck,1982124315326Hochberg, M.C.,19974017251725Hodgin, J.B., J. Whelan, G.S. Markowitz and M.B. Stokes,200953513517Jeruc, J., V. Jurcic, A. Vizjak, A. Hvala and N. Babic et al.,2000112702706Kuzniar, J., Z. Marchewka, J. Lembas-Bogaczyk, T.J. Kuzniar and M. Klinger,200498814Liangos, O., M.C. Perianayagam, V.S. Vaidya, W.K. Han and R. Wald et al.,200718904912Manson, J.J. and A. Rahman,20062006Marks, S.D., V. Shah, C. Pilkington, P. Woo and M.J. Dillon,200520141148Masuda, T., T. Akimoto, Y. Ando, T. Kobayashi and D. Meguro et al.,200847287290Mohrmann, M., S. Ansorge, U. Schmich, B. Schonfeld and M. Brandis,19948157163Mori, Y., N. Kishimoto, H. Yamahara, Y. Kijima and A. Nose et al.,200597984O'Dell, J.R., R.C. Hays, S.J. Guggenheim and J.C. Steigerwald,198514519961999Olsen, K.M., M.I. Rudis, J.A. Rebuck, J. Hara and D. Gelmont,20043216781682Petri, M., N. Kasitanon, S.S. Lee, K. Link and L. Magder et al.,20085817841788Pitashny, M., N. Schwartz, X. Qing, B. Hojaili, C. Aranow, M. Mackay and C. Putterman,20075618941903Ponticelli, C., G. Banfi and G. Moroni,20052005pp: 824-842pp: 824-842Ren, L., J. Ji, Y. Fang, S.H. Jiang and Y.M. Lin et al.201139647653Cameron, J.S.,199910413424Ter Borg, E.J., P.E. de Jong, S.S. Meijer and C.G.M. Kallenberg,1991111622Tsai, C.Y., T.H. Wu and C.L. Yu,200085207214Weening, J.J., V.D. D'Agati, M.M. Schwartz, S.V. Seshan and C.E. Alpers et al.,200415241250Wellwood, J.M., R.G. Price, B.G. Ellis and A.E. Thompson,1976698591Yu, F., L.H. Wu, Y. Tan, L.H. Li and C.L. Wang et al.,201077820829Zoja, G., A. Benigni and G. Remuzzi,19997420428