Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.1998.274.276BaigMuhammad Iqbal NawazMuhammad IqbalMuhammad Zafar 4199814The urinary excretion and metabolism of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) were determined in goats following intravenous injection of a single dose 50 mg/kg body weight. The percentage of intravenous dose of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) excreted in the urine until 24 hour as total amine was 61.0 ± 5.2 per cent, free amine 43.2 ± 4.6 per cent and acetyl amine was 17.8 ± 1.2 per cent. The mean ± SE values for relative percentage of Metabolite I identified as unchanged amine was 42.3 % Metabolite II acetyl amine was 15.67 per cent, Metabolite III hydroxy derivative 18.33 and as conjugated Metabolite were 23.33 per cent. In goats, the urinary excretion and Metabolism of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) revealed differences appprising as adjustment dosage regimen in the indigenous goats.]]>Atef, M. and P. Nielsen,19755167172Bratton, A.C. and E.K. Marshall,1939128537550Bridges, J.W., S.R. Walker and R.T. Williams,1969111173179Nawaz, M. and F.H. Khan,19792129132Nawaz, M. and B.H. Shah,19851985Nawaz, M.,19881988Nawaz, R., S. Parveen, B. Saleem and M. Nawaz,198562532Nawaz, R., N. Zahara, M. Nawaz and B.H. Shah,198663236Nawaz, R., A. Ilahi and M.Z. Iqbal,199212116120Sharan, K.K. and N.C. Banerjee,198252228231