Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.1999.1027.1029RahimM. SiddiqueM. SindhuS.T.A.K. Ali KhanMirza 3199923Eighty, day-old broiler chicks were primed with live ND and IBD vaccines at 7 and 9 days of age and boosted at the age of 21 and 28 days, respectively. At 3 weeks of age, chicks were divided into 5 equal groups A, B, C, D and E. Groups A, B and C were fed on aflatoxin contaminated feed and 1, 2 and 3 g of Hydrated Sodium Calcium Alumino Silicate (HSCAS)/kg of feed respectively. Group D was raised on contaminated feed without binder (positive control) and group E on normal feed without binder (negative control) for a period of four weeks. Maximum body weight gain was observed in group E and minimum in group D. There was a dose related increase in the weight gains of groups A, B and C. The minimum HI titres against NDV were found in group D and maximum in group E. The gradually increasing dosage of the binder in the feed of groups A, B and C manifested a dose related increase in HI antibody titres. Maximum IHA titres against IBD were found in group E and minimum in group D. Groups A, B and C also manifested a dose related increase in IHA titres against IBD. The mortality recorded in groups A, B, C, D and E was 31.25, 18.75, 18.75, 43.75 and 0.0 percent, respectively. Mycotoxin-binder at the rate of 3 g/kg of feed gave better results in terms of body weight gain, humoral immune response and better protection against aflatoxicosis compared to the dose rates of 1 and 2 g/kg of feed.]]>Abo-Norag, M., T.S. Edrington, L.F. Kubena, R.B. Harvey and T.D. Phillips,199574626632 Afzal, M., R.A. Cheema and R.A. Chaudhary,197969149151Arshad, S., M.Z. Khan, M. Siddique, M.T. Javed and H.A. Khan,199212183185Balachandran, C. and R. Ramakrishnan,198764911914Boulton, S.L., J.W. Dick and B.L. Hughes,19822616Chaudhary, R.A. and H. Afzal,19821111113Ghosh, J.D., J. Singh, S.K. Mahipal and R.C. Kulshreshtha,199060725727Huff, W.E., L.F. Kubena, R.B. Harvey and T.D. Phillips,1992716469llgaz, A.,198596272Jones, B.D.,19721972Ketterer, P.J., B.J. Blaney, C.J. Moore, I.S. McInnes and P.W. Cook,198259113118Kubena, L.F., R.B. Harvey, T.D. Phillips and B.A. Clement,1992714848Mishra, N.K. and S.K. Daradhiyar,19915712231226Mohiuddin, S.M.,1993266363Murthy, A.S., M. MaHender and P.R. Rao,1986157477Rizvi, S.A.R. and A.R. Shakoori,1992245358Sabri, M.A., M. Siddique, M.Z. Khan and H.A, Samad,19899106108Siddique, M. and T. Javed,198991827Tuekam, T.D., R.D. Miles and G.D. Butcher,19921992Weibking, T.S., D.R. Leudox, A.J. Brmudz and G.E. Rottinghaus,19921992