Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2000.1104.1106NafeesaAsma Tahira Iqbal Munir A. Shiekh M. Nawaz Amer Jamil 7200037The biodisposition kinetin and urinary excretion of kanamycin was investigated in eight normal adult female goats of beetle breed after intravenous close of 5 mg/kg to each gear. After single intravenous administration of kanamycin. in goats, the distribution half-life and biological hall-life had average of 8.1±0.893 min and 2.87±0.12 hrs and ranged between 4.28 to 11.61minutes and 2.44 to 3.37 hrs respectively. The aapparent volume of distribution of kanamycin in goat calculated by area method was 584.6±34.21 mg/kg. The rate constants for Lananivein transfer across compartment 1 to 2, K12 and 2 to 1, K21 were 1.846±0.316 hr1 and 3.800±0.434 hr and ranged between 1.016 to 3.713 hr1 and 2.45 to 5.77 hr1, respectively. Total body clearance of kanarnycin calculated on per kg basis ranged 1.79 to 3.59 ml/min/kg with an average value 2.389±0.194 ml/min/kg, Cumulative urinary excretion as percent of total does excreated at 12 hours was 10.266±1.233. The studies showed variation in pharmacokinetic behaviour of kanamycia in indigenous goats as compared to earlier studies.]]>Akhtar, P.,19871987Arret, B., D.D. Johnson and K. Amiel,197160373378Baggot, J.D.,1977Baggot, J.D.,19781163170Baggot, J.D., D.N. Love, R.J. Rose and J. Raus,19814277284Feodorov, V., E. Chaleva, D. Kazachka and G. Naneva,1987242835Firth, E.C., W.R. Klein, J.F.M. Nouws and T. Wensing,1988115662Fox, K.E. and N.J. Russell,1987Rana catesbeiana.]]>87245250Gast, R.K. and J.F. Stephens,198867689698George, L.W., M. ReinaâGuerra, J.D. Baggot and J. Mihalyi,19869183191Gibaldi, M.,1984Kirby, W.M., J.T. Clarke, R.D. Libke and C. Regamey,1976134S312S315Lashev, L.D., D.A. Pashov and T.N. Marinkov,199216293300Nawaz, M. and B.H. Shah,19851985Nawaz, M., T. Iqbal and R. Nawaz,19882260260Rule, R., C. Lanusse and C.J. Errecalde,19886251257Treppenhauer, H.J.,197380473477Yamasaku, F., Y. Suzuki, S. Shinkai, T. Shomura and I. Komiya,198634S117S128