Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2000.411.414Bufo regularis) as Reliable Biological
Test Animals for Screening Chemicals and Drugs Which Induce Leukaemia in Man. I: The Effect of Nizoral (Ketoconazole) on Leucocytes of Toads and Mice]]>El-MoftyM.M. A.E. Essawy M.H. Shwairebv H.M. Abdel-Karim 3200033Nizoral (Ketoconazole) is an antifungal drug used for the treatment of systemic mycosis and mucocutaneous candidiasis. Administration of Nizoral into toads and mice induced pronounced alterations in leucocytes. Electron microscopical examination revealed that these alterations are leukaemic alterations and they are more or less similar to the criteria reported in human Leukaemia. The changes were all comparable to those observed after the administration of the carcinogenic chemical 7,12 dimethylbenz (a) anthracene.]]>Bennett, J.,19911991De Coster, R., I. Caers, C. Haelterman and M. Debroye,198529489493DeFelice, R., D.G. Johnson and J.N. Galgiani,19811910731074Dickersin, G.R.,1988El-Mofty, M.M., N.E. Abdelmeguid, I.A. Sadek, A.E. Essawy and E. Abdel-Aleem,19974657660El-Mofty, M.M., N.E. Abdelmeguid and A. Essawy,19952167170El-Mofty, M.M., M. Reuber, I. Sadek, I. Sabry and S. Bayoumi,1981Bufo regularis as a biological test animal.]]>1981pp: 96Ghadially, F.N.,19852nd Edn.,Heel, R.C., R.N. Brogden, A. Carmine, P.A. Morley, T.M. Speight and G.S. Avery,198223136Jones, H.E., J.G. Simpson and W.M. Artis,1981117129134Komiyama, A., M. Ogawa, K. Eurenius and S.S. Spicer,1976100590594Lake-Bakaar, G., P.J. Scheuer and S. Sherlock,1987294419422Loose, D.S., P.B. Kan, M.A. Hirst, R.A. Marcus and D. Feldman,19837114951499Razzouk, C., E. Agazzi-Leonard, J. Cumps, F. Poncelet, M. Mercier and M. Roberfroid,19788510071016Stevens, D.A., P.L. Williams, A.M. Sugar and A. Pont,198297284285Vanden Bossche, H., D. Bellens, W. Cools, J. Gorrens and P. Marichal et al.,19868287298