Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2002.1098.1100HameedAmjad IqbalTahira NawazMuhammad BatoolFaiz Tabassum BaigTayyba AliShafaqat NurjisFarwa 102002510Ofloxacin a synthetic fluorinated analog of nalidixic acid is broad spectrum antibiotic. This study was designed to find pharmacokinetics of ofloxacin in healthy male volunteers under indigenous conditions. A total of 15 healthy male volunteers were included in this study. Ofloxacin (200 mg) was administered orally and blood samples were collected at different time intervals. The blood samples were analyzed for drug concentration by microbiological assay. The plasma concentration verses times data was used to determine pharmacokinetics parameters by one compartment model kinetic analysis. The mean (SD) values for different parameters were, absorption rate constant (Ka) 7.833 (8.683) l h -1, area under curve (AUC) 14.545 (4.304) h, mg l -1, total body clearance (CI) 14.913 (4.373) l h -1, volume of distribution (Vd) 130.76 (25.598) l, elimination half life (t1/2 ) 6.419 (1.789) h, elimination rate constant (k10 ) 0.154 (0.139) l h -1, mean residence time (MRT) 10.104 (2.384) h, absorption half life (t1/2α ) 0.212 (0.151) h, time to maximum concentration (tmax) 1.397 (0.599) h and maximum concentration (Cmax) 1.416 (0.305)micro grams ml -1. Values of parameters like Vd, AUC and Cl were comparable with foreign studies. While t1/2β , Ka were higher, and C max , tmax were lower in local population as compared with the foreign studies.]]>Arret, B., D.P. Johnson and A. Krishbaum,197160373378Corvaisier, S., N. Bleyzac, M. DeMontclos, M. Druguet, G. Aldrand, G. Carret and P. Maire,199954223231Eboka, C.J., R.S. Okor, J.O. Akerele and S.O. Aigbavboa, 199723217220Echols, R., M.P. Weinstein, B. Okeefe, A. Shah and A.H. Heller,199418487492Flor, S., D. Guay, J. Opsahl, K. Track and G. Matzke,199111115121Guay, D.R., J.A. Opsahl, F.G. Mcmahom, R. Vargas, G.R. Matzke and S. Flor,199236308312Guay, D., K. Track and S. Flor,199111203209Israel, D., J.G. Gillum, M. Turik, K. Harvey and J. Ford et al., 19933721932199Lamp, K.C., E.M. Bailey and M.J. Ryback,1992223246Molinaro, M., P. Villani, M.B. Regazzi, R. Roundanelli and G. Doveri,199243105107Rombout, F.,19871987Stein, G.E., M.L. Bel, S.C. Flor and M. Zinny,199112479484Verho, M., V. Malerezyk, D. Damm and K.H. Lehr,1996135767Yuen, G.J., G.L. Drusano, J. Brooks and S. Flor,1992128892Yuk, J.H., C.H. Nightingale, R. Quintiliani and K.R. Sweeney,199135384386Baggot, J.D.,1977pp: 117-118pp: 117-118Goodmann, L.S., A.G. Gillman, T.W. Rall and F. Murad,19857th Edn.,pp: 490pp: 490Katzung, B.G.,1998Nawaz, M.,19941617273Nawaz, M. and B.H. Shah,19851985Nawaz, M., T. Iqbal and R. Nawaz,198825757Zhuo, H.T., J.Z. Lu, X.R. Xia and S.S. Ling,199415411413Orlando, R., A. Sawadogo, P.A. Miglioli, M.G. Cappellazzo and P. Palatini,19923816