Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2003.1399.1403RashidSaba BhattiHaq NawazIjazAmbreen SadafBazgha AhmedSarfraz 122003616Renal clearance of endogenous creatinine and acetylsalicylic acid was investigated in 12 healthy
male volunteers. Blood and urine samples were collected at pre-determined time intervals. The
concentration of acetylsalicylic acid (as salicylates) and creatinine in plasma and urine were
determined colorimetrically. Mean ±SE values were found to be, for diuresis 0.031±0.011 mLmin‾1
kg1, Plasma concentration of creatinine and salicylic acid 15.11±0.166 μg mL1 and 29.38±0.12
μg mL1, urine concentration of creatinine and salicylic acid 855.73±1.53 μg ml1 and 38.30±0.43
μg mL1, renal clearance of creatinine and salicylic acid 1.52±0.08 ml min1 kg1 and 0.063±0.02
mL min1 kg1 and clearance ratio 0.054±0.016. The results indicated that there is less renal
clearance of acetylsalicylic acid in local environment when compared with values given in literature.]]>Bonsnes, R.W. and H.H. Taussky,1945158581591Borga, O., I. Ordar-Cedelof, V.A. Ringberger and A. Norlin,197620464475Done, A.K.,196026800807Farid, N.A., G.S. Born, W.V. Kessler, S.M. Shaw and W.E. Lange,19752111671168Fatima, K.,20022002Ganong, F.W.,199718th Edn.,pp: 653-655pp: 653-655Girdwood, R.H.,197924th Edn.,pp: 177pp: 177Ijaz, A.,20022002Majeed, B., H.N. Bhatti and K. Fatima,2003611911194Nawaz, M. and B.H. Shah,198436220224Punnon, K. and U. Pekka,198415177185Rashid, F.,19981998Reynolds, J.E., F.K. Parfitt, A.U. Parson and S.C. Sweetman,1989pp: 32pp: 32Steel, R.G.D. and J.H. Torrie,1992Simon, L.S. and J.A. Mills,198030211791179Martens, J. and F.P. Meyer,1995504143