Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2003.1404.1407IjazAmbreen BhattiHaq NawazRasheedSaba SadafBazghah NawazRakhshanda 122003616The pharmacokinetics of acetylsalicylic acid, a non-steroidal anti-inflammatory agents, was studied
in twelve healthy young females after oral administration of 600 mg aspirin. Blood samples were
collected at pre-determined time intervals. The concentration of aspirin as free salicylic acid was
analyzed colorimetrially at 530 nm and mean ±SE value in blood was found to be 30.33±0.63 μg
mL1. Individual pharmacokinetic parameters were estimated by using two compartment open
model. Mean±SE values were found to be Cmax 44.54±0.46 mg L1, tmax 1.87±0.05h, t1/2α 1.17±0.25
h, Ka 0.85±1.12 h1, AUC 275±2.73 h.mg L1, Vd 10.90±0.76 L, t1/2β 4.69±0.55 h and TBC
1.68±0.06 L h1. ASA values established in this study were in agreement with those reported by
other authors.]]>Aamir, M.,20022002Baggot, J.D.,19771st Edn.,pp: 144-189pp: 144-189Done, A.K.,196026800807Furst, D.E., T.N. Tozer and K.L. Melmon,197926380389Levy, G. and T. Tsuchiya,1972287430432Martens, J. and F.P. Meyer,1995504143Mason, W.D. and N. Winer,198170262265Montgomery, P.R. and D.S. Sitar,198672125Nawaz, M.,199472307307Punnon, K. and U. Pekka,198415177185Rombout, F.,19911991Reynolds, J.E., F.K. Parfitt, A.U. Parson and S.C. Sweetman,1989pp: 32pp: 32Siebert, D.J., F. Bochner, D.M. Imhoff, S. Watts, J.V. Lloyd, J. Field and B.W. Gabb,198333367374Steel, R.G.D. and J.H. Torrie,1992Stein, B., V. Fuster, D.N. Israel, M. Cohen, L. Badimon, J.J. Badimon and J.H. Chesebro,198914813836Dubovska, D., V.K. Pitrovskij, M. Gajdos, Z. Krivokikova, V. Spustova and T. Trnovec,1995176777Simon, L.S. and J.A. Mills,198030211791185