Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2006.2156.2158YanJin-Long 112006911To establish method for the determination of fluvastatin sodium in Loscol capsule, the electrochemical behavior of fluvastatin sodium on a glassy carbon electrode was investigated by cyclic voltammetry, linear sweep voltammetry and differential pulse voltammetry. It was found that fluvastatin sodium would give a sensitive oxidation peak at +0. 64 V in the HAc-NaAc buffer solution (pH 5.10) under the Differential Pulse Voltammetric (DPV) mode. The peak current was linear with the concentration of fluvastatin sodium in the range of 2.0~40 mg L-1. Based on which, a DPV method for determination of fluvastatin sodium with the detection limit of 0.24 mg L-1 has been developed. The proposed method has been used for determination of fluvastatin sodium in the Loscol capsule, the recovery was found to be in the range of 98.0~101.2%. The mechanism for this electrochemical reaction at the glassy carbon electrode was also discussed in this study. The electrochemical analysis method described here enables simple and rapid determination of fluvastatin sodium in real samples.]]>Akinori, N., S. Christoph, N. Miyuki, M. Naoki, I. Kazuhide and F. Kotaro,20017601725Erk, N.,200257817819Leis, H.J. and W. Windischhofer,200519128132Sibel, A.O. and U. Bengi,2002372582586Zhen, Y. and M. Hongyan,1997910061009