Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2006.783.787Schistosoma mansoni and Schistosomamargrebowiei Infections]]>KalhoroI. B.4200694Comparative histopathological and histochemical studies on the gut damage following infections with Schistosoma mansoni and Schistosomamargrebowiei were showed after 42, 49, 77, 91, 105 and 119 days post infection (d.p.i) in definitive host mouse. The prominent histopathological changes were thinning of epithelial cells and variable shape of the goblet cells. Most of the villi were shrunken, crackling and tips were damaged. Increases spaces and infiltration of the granulocytes were observed in lamina propria of the tunica mucosa. The granulomas with single or multiple eggs were mainly surrounded by variety of connective tissues observed in the submucosa, tunica muscularis and tunica serosa from 42 to 119 d.p.i. in S. mansoni and in S. margrebowiei from 77 to 119 d.p.i. S. mansoni eggs produced a minimum cellular reaction in the lamina propria of tunica mucosa from 91 to 119 d.p.i. A few eggs were seen in the blood vessels of the submucosa from 42 to 119 d.p.i. in S. mansoni. Due to infections swollen walls with enlarged endothelial cells of the blood vessels were observed. Fibrosis was seen in the tunica muscularis and tunica serosa from 91 to 119 d.p.i. A few areas of early necrosis were also observed in the tunica submucosa and tunica muscularis from 91 to 119 d.p.i. in both parasite species. Normal and infected brush borders, epithelial cells, goblet cells, muscular cells, connective tissues in the lamina propria of tunica mucosa and submucosa were positive for protein. The most prominent changes were increase of protein in paneth cells present in the crypts of gut during infections. Significantly increased amount of glycogen and acid mucopolysaccharides was observed in the goblet cells. Thin granules of glycogen were positively stained in the brush borders and also muscular cells of the tunica muscularis. Ribonucleic acid was stained positively in epithelial cells, connective tissues and muscular cells. Endothelial cells were stained weekly for ferric irons and lipofuscin pigments.]]>Allen, G.P.R., P.B. Bartley, A.C. Sleigh, G.R. Olds, Y. Li, G.M. Williams and D.P. McManus,200234612121220Andrade, Z.A. and T. Barka,1962111216Bethlem, E.P., G. Schettino and C.R. Carvalho,19973361365Brown, E.B., J.R. Dubach and Moore,195852335335Brown, P.J., B.J. Miller, C.R. Stokes, N.B. Blazquez and F.J. Bourne,198898313323Cheever, A.W., R.H. Duvall and R.G. Minkar,1980Schistosoma japonicum and the relation of intestinal lesions, passage of eggs in the facces.]]>2913161326Cheever, A.W. and R.H. Duvall,1982Schistosoma japonicum: Migration of adult worm pairs within the mesenteric veins of mice.]]>76641645Chen, M.C., S.C. Wang and P.Y. Chang,19784371378Chen, M.G.,1991Schistosoma japonicum eggs in the intestine of man: A subject of inconsistency.]]>48163171Chen, M. and K. Mott,1989Schistosoma japonicum infection: A review of recent literature.]]>85156Chodos, R.B., J. Fross, I. Apt, M. Pollycove and J.A.E. Halket,195736314326Cooke, G.S., A. Lalvani, F.V. Gleeson, C.P. Conlon,199929836839Doherty, J.F., A.H. Moody and S.G. Wright,199631310711072Finch, C.A.,19505983983Schalm. O.W.,19652nd Edn.,pp: 347pp: 347Fujino, T., H. Ichikawa, B. Fred and K. Fukuda,1993Echinostoma trivovis (Cort, 1914) Kanev, 1985 and reaction of E. caproni Richard, 1964 Trematoda: Echinostomatide) in C3H mice: Pathological, ultrastructural and cytochemical effects on the host intestine.]]>79286292Fujino, T., H. Ichikawa, B. Fred and K. Fukuda,1996Echinostoma trivolvis: Suppressive effects of dexamethasone on goblet cell hyperplasia and worm rejection in C3H/HENmice.]]>3283289Hirata, M., M. Takushima, M. Kage and T. Fukma,1993Schistosoma japonicum eggs in mice.]]>79316321Hussein, A., S. Medany, A.M. Abou el Magd, S.M. Sherif and C.B. Williams,19831673674James, S.L. and D.G. Colley,1976Schistosoma mansoni eggs.]]>20359374Kloetzel, K.,1970Schistosoma mansoni eggs II. Distribution of eggs in feces and at different levels of the intestinal wall, at variable intervals after infections.]]>64116121Ojo, O.S., W.O. Odesanmi and O.O. Akinola,1992136469Poon, R.T. and K.W. Chu,199923713716Sasa, M.,1972Schistosomiasis Japonica.]]>1972pp: 235-61pp: 235-61Soomro, N.M.,19961996Spicer, S.S., M.G. Wetzel and B.K. Wetzel,19671225225Von Lichtenberg, F., E.H. Sadun, A.W. Cheever, D.G. Erickson, A.J. Johnson and H. Boyce,1971Schistosoma japonicum in chimpanzee: Parasitological, clinical, serological and pathological observations.]]>20850893Warren, K.S.,19821982pp: 150-164pp: 150-164Yu, X., P. Chen, J. Xu, S. Xiao, Z.J. Shan and S.J. Zhu,19911046470Zhou, H., A.G.P. Ross and G.F. Hartel,1998Schistosomiasis japonica in Chinese schoolchildren by administration of a questionnaire.]]>92245250