Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.318.321Candida albicans]]>HolakuyeeMarzieh Hossein YadegariMohammad Mohammad HassanZuhair MahdaviMehdi 22007102In this study, anti proliferative activity of structural proteins and fraction of supernatant from culture of Candida albicans on proliferation responses of lymph node cells in Balb/c mice have been evaluated. For this reason Candida albicans was cultured in RPMI medium supplemented with 10% FBS at 37 in%5 CO2 until reaching a confluent state for 2 weeks. The culture supernatant was obtained by centrifugation and purified by gel filtration chromatography and structural proteins of C. albicans were obtained from breakage of cell wall by vortexing with glass beads in suspension of PBS and 1 mM PMSF and then cultured with lymph node cells and evaluated by MTT assay. The results in this study demonstrated that both of structural proteins and fraction of supernatant from culture of Candida albicans suppress immune responses compared with Control group. Our study provides evidence that proteins of C. albicans have anti proliferative activity.]]>Chinen, T., M.H. Qureshi, Y. Koguchi and K. Kawakami,1999Candida albicans suppresses nitric oxide (NO) production by interferon-gamma (IFN-γ) and lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages.]]>115491497Elorza, M.V., A. Murgui and R. Sentandreu,1985Candida albicans: Contribution of mannoproteins to the architecture of yeast and mycelial cell wall.]]>1311220912216Martinez, J.P., M.L. Gil, J.L. Lopez-Ribot and W.L. Chaffin,1998Candida albicans.]]>1121141Known-Chung, K.J. and J.E. Bennet,1992pp: 300-302pp: 300-302Murciano, C., E. Villamon, J.E. Oconnor and M.L. Gil,2006Candida albicans yeasts and hyphae inhibit gamma interferon release by murine natural killer cells.]]>7414031422Newman, S.L. and A. Holly,2001Candida albicans is phagocytosed, killed and processed for antigen presentation by human dendritic cells.]]>6968136822Podzorski, R.P., H.J. Herron, D.J. Fast and R.D. Nelson,198912412901294Rantala, A.,1993205150Smail, E.H., D.A. Melnick, R. Ruggeri and R.D. Diamond,1998Candida albicans hyphae causing dissociation of the neutrophil respiratory burst response to chemotactic peptides from other post-activation events.]]>14038933899Tang, N., L. Liu, K. Kang, P.K. Mukherjee and M. Takahara et al.,2004Candida albicans via selective activation of erk mitogen-activated protein kinase.]]>7225132520Torosantucci, A., G. Romagnoli, P. Chiani and R. Nisini,2004Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: A novel dimorphism-dependent mechanism to escape the host, simmune response.]]>72833843Verduyn Lunel, F.M., J.F. Mels and A. Voss,199934213220Wenzel, R.P. and M.A. Pfaller,199112523524