Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.409.414SimporeJacques IlboudoDenise DamintotiKarou SawadogoLuc MariaEsposito BinetScott NitiemaHenri OuedraogoPaul PignatelliSalvatore NikiemaJean-Baptiste 32007103Where malaria is endemic, there is an unexpected association between
haemoglobinopathies and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.
Their coexistence in a patient with sickle cell disease (SCD) can lead
to hemolytic anemia, hemoglobinuria, sepsis, renal failure and vaso-occlusive
attacks (VOA). The aim of this research was to determine the impact of
G-6-PD deficiency in SCD patients. That is why, we screened haemoglobinopathies
and G-6-PD deficiency in 7 villages and at 10 primary schools in Kadiogo
Province, Burkina Faso. Hemoglobin electrophoresis was performed on blood
from 18,383 people. From these results, we chose 342 subjects for a hemogram
and the measure of the G-6-PD activity. The results were analyzed with
EpiInfo-6 and Spss-10. Statistical significance was set at p<0.05.
We found a prevalence of 28.9% of Sickle Cell Trait (SCT), 1.3% of Major
Sickle Cell Syndromes (MSCS), 12.3% of G-6-PD deficiency among women and
20.5% among men. We did not detect a statistically significant difference
for counts of erythrocytes (p = 0.773), leucocytes (p = 0.227) and reticulocytes
(0.292); hemoglobin levels (p = 0.998); annual vaso-occlusive attacks
(p = 0.869) between persons with SCD having a G-6-PD deficiency and those
with normal G-6-PD activity. According to this study, G-6-PD deficiency
does not seem to increase the severity of SCD. However, these patients
should know their G-6-PD genotype in order to avoid consuming oxidative
drugs that might provoke oxidative stress.]]>Akoglu, T., F.L. Ozer and E. Akoglu,1986123677680Ali, N., M. Anwar, M. Ayyub, F.A. Bhatti, M. Nadeem and A. Nadeem,200515137341Allison, A.C.,195448312318Balgir, R.S.,200532560573Bienzle, U., O. Sodeinde, C.E. Effiong and L. Luzzatto,197546591597Bouanga, J.C., R. Mouele, C. Prehu, H. Wajcman, J. Feingold and F. Galacteros,199848192197Ciftci, M.,2005in vitro.]]>20485489Diallo, D., A.K. Traore, M. Baby, A.A. Rhaly, G. Bellis and A. Chaventre,199435551554Diop, S., D. Thiam, A. Sene, M. Cisse, K. Fall and A.O. Toure-All et al.,20004777Diop, S., A. Sene, M. Cisse, A.O. Toure and O. Sow et al.,2005505660El-Hazmi, M.A. and A.S. Warsy,1986362430El-Hazmi M.A. and A.S. Warsy,1987393235Enevold, A., L.S. Vestergaard, J. Lusingu, C.J. Drakeley and M.M. Lemnge et al.,20054461Fleming, A.F., J. Storey, L. Molineaux, E.A. Iroko and E.D. Attai,197973161172Gbadoe, A.D., K .Atsou, O.A. Agbodjan-Djossou, E. Tsolenyanu and M. Nyadanu et al.,200194101105Ghani, R., M.A. Manji and N. Ahmed,200233855861Gupte, S.C., P.U. Patel and J.M. Ranat,2005595156Jacob, E., J.E. Beyer, C. Miaskowski, M. Savedra, M. Treadwell and L. Styles,200529392400Kaplan, M., M. Muraca, H.J. Vreman, C. Hammerman and M.T. Vilei et al.,200590F123F127Labie, D., C. Richin, J. Pagnier, M. Gentilini and R.L. Nagel,198465300302Laosombat, V., B. Sattayasevana, T. Chotsampancharoen and M. Wongchanchailert,200683139143Lewis, R.A., R.W. Kay and M. Harthorn,196636399411Lewis, R.A.,197350105111Luzzatto, L. and N.C. Allan,196821910411042Mockenhaupt, F.P., B. Rong, M. Gunther, S. Beck and H. Till et al.,200094477483Modiano, D., G. Luoni, B.S. Sirima, J. Simpore and F. Verra et al.,2001Plasmodium falciparum malaria.]]>414305308Modiano, D., G. Luoni, B.S. Sirima, A. Lanfrancotti and V. Petrarca et al.,2001Plasmodium falciparum malaria of Fulani of Burkina Faso (West Africa) is associated with low frequencies of classic malaria-resistance genes.]]>95149152Muzaffer, M.A.,200512170171Ozmen, I. and O.I. Kufrevioglu,200450499504Rattazzi, M.C., L.M. Corash, G.E. van Zanen, E.R. Jaffe and S. Piomelli,197138205218Rogers, Z.R.,200519917928Saad, S.T. and F.F. Costa,199242125128Samuel, A.P.W., N. Saha, J.K. Acquaye, A. Omer, K. Gameshagura and E. Hassounh,198636107112Shimizu, H., M. Tamam, A. Soemantri and T. Ishida,200550420424Simpore, J., S. Pignatelli, S. Barlati and S. Musumeci,200226121127Singh, S., D.K. Singh, R. Gupta, S. Nigam and T. Singh,2006116365Steinberg, M.H. and B.J. Dreiling,197480217220Storey, J., A.F. Fleming, R. Cornille-Brogger, L. Molineaux, T. Matsushima and I. Kagan,197973311315Trabuchet, G., J. Elion, O. Dunda, C. Lapoumeroulie and R. Ducrocq et al.,199187597601Williams, T.N., T.W. Mwangi, S. Wambua, N.D. Alexander and M. Kortok et al.,20051178186Znaidi, R., R. Hafsia, A. M'Rad, R. Kastally and A. Hafsia,199573415417