Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.2154.2158AjeigbeK.O. OlaleyeS.B. NwobodoE.O. 1220081117In this study, the effects of two antimalarials-amodiaquine
hydrochloride and artemisinin were investigated in ulcerated albino rats
of Wistar strain. Rats were treated with amodiaquine (30 mg kg-1)
and Artemisinin (2.86 mg kg-1) for 24 h after formation of
ulcers induced by indomethacin. Treatments with Amodiaquine Hydrochloride
led to significantly increased gastric lesions while artemisinin led to
significantly decreased gastric lesions. Also, amodiaquine hydrochloride
seemed to elaborate the indomethacin induced effects on gastric juice
volume, pH and acid output, while artemisinin attenuated these changes.
The data indicates that the use of amodiaquine hydrochloride may be dangerous
to the integrity of the stomach, especially in existing gastric ulcers,
while artemisinin is mild and ameliorating, may result from their lipid
peroxidation/apoptosis activity interference.]]>Adjuik, M., P. Agnamey, A. Babiker, S. Borrmann and P. Brasseur et al.,200235913651372Ajayi, A.A., A. Oluokun, O. Sofowora, A. Akinleye and A.T. Ajayi,198937539540Christopher, J.S., Z. Yan, M. Carol, M. Koboldt and S.Z. Ben et al.,1998951331313318Corne, S.J., S.M. Morrissey and R.J. Woods,1974242116P117PDesai, J.K., R.K. Goal and N.S. Parmar,199741315Etimita, Y.O., S.A. Bisong, A.B. Antai, C.O. Nku and E.E. Osim,2005206973Gustafsson, L.I., O. Walker, G. Alvan, B. Beermann and F. Esterverz et al.,198315471479Hawkey, C.J.,2003119521535Ibironke, G.F., S.B. Olaleye, O. Balogun and D.A. Aremu,1997Garcinia kola (Heckel) on gastric acidity and experimental ulceration in rats.]]>11312313Ishizuka, Y., T. Kamisai and M. Sato,199646919922Kapui, Z., K. Boer, I. Rozsa, G. Blasko and I. Hermecz,199343767771Levine, L.,2001653135Ma, L., W.P. Wang, J.Y. Chow, S.T. Yuen and C.H. Cho,2000278G10G17Mawdsley, J.E. and S. Rampton,200613327336Nosten,F., M. Van Vugt, R. Price, C. Luxemburger and K.L. Thway et al.,2000Plasmodium falciparum malaria and mefloquine resistance in Western Thailand: A prospective study.]]>356297302Olaleye, S.B., O.A. Adaramoye, P.P. Erigbali and O.S. Adeniyi,20071351215126Olliaro, P.L. and W.R.J. Taylor,200320637533759Phillips, R.S.,200014208226Reeves, J.J. and R. Stables,198586677684Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan,2004Nigella sativa and its extracts in indomethacin treated rats.]]>79951000Rostom, A., G. Wells, P. Tugwell, V. Welch, C. Dube and J. McGowon,20002722032214Tanaka, T., Y. Morioka and U. Gebert,199343558562Targett, G., C. Drakeley, M. Jawara, L. Von Seidlein and R. Coleman et al.,2001Plasmodium falciparum to Anopheles gambiae.]]>18312541259White, N.J.,1997in vivo.]]>4114131422White, N.J.,200411310841092White, N.J.,199941301308WHO,20012001Yamaguchi, N. and T. Kakizoe,2001Helicobacter pylori and gastric cancer.]]>28894