Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.2413.2417JohariH. ParhizkarZ. TalebiE. 1220081120The present study was undertaken to investigate effects
of the adenine on the hypothalamus- pituitary-gonad axis and changes in
blood hormone concentration such as FSH, LH, progesterone and estrogen
in newborn female rats. Adenine is a common organic base and its concentration
variations caused by foods, has various effects on the body metabolic
systems. In present study, fifty newborns rats were used divided into
five groups, of 10s, including control I, control II which received solvent
(normal saline) only and three experimental groups which received 50,
100 and 200 mg body weight adenine respectively. All the animals were
kept under same condition with plenty food and water and treated Intra
Peritoneally (IP) during days 2-16 after birth. At the end of experiment,
all the animals were weighed, their ovaries were removed and blood samples
were taken for hormone analysis. The results showed that dose dependent
adenine solution significantly reduced the body and ovarian weight on
30 and 70 days after birth. In addition adenine led into no significant
difference in concentration of FSH and LH in the experimental groups relative
to the control on 30th day of life. But on the 70th day, the levels of
these hormones raised significantly in the experimental groups. Furthermore,
the adenine solution significantly increased the levels of progesterone
and estrogen hormones in the experimental groups relative to the control
on the 30th day, while decreased their concentration significantly on
the 70th day. This situation has close similarities to metabolic disorders
present in human caused by excessive use of adenine. High amounts consumption
of adenine in can lead into hormone abnormality, weight loss and metabolic
anomalies.]]>Abraham, A.K.,198159368373Aronica, S.M. and B.S. Katzenellenbogen,199112820452052Bethell, D.R., H. Hibasami and A.E. Pegg,1982243262269Chen, K.Y. and A.Y. Liu,19811347174Damassa, D.A., E.R. Smith, B. Tennent and J.M. Davidson,19778275286Danialzadeh, A. and K. Zareian,20013rd Edn.,De Kretser, D.M., R.C. Atkins and C.A. Paulson,197358425434Hatse, S., L. Naesens, E. De Clerq, M. Vandeputte, M. Waer, C. Segers, B. Degreve and J. Balzarini,199876595600Holdsworth, S., R.C. Atkins and D.M. De Kretser,197729612451249Houghton, M.,20064th Edn.,Gray, J.A. and R.G. Kavlock,1991431926Huang, H.F., M.T. Li, S. Wang, L.M. Pogach and J.E. ottenweller,2003266978Knecht, M.J., M. Darbon, T. Ranta, A.J. Baukal and K.J. Catt,19841154149Levy, M. and R. Brene,19903rd Edn.,Mamont, P.S., M.C. Duchesne, J. Grove and P. Bey,1978815866Muller, M., A. Dorn, H.G. Bernstein, A. Pajunen and M.J. Arvinen,1986336197199Nazian, S.J. and J.R. Dietz,198737105111Pegg, A.E., K. Shuttleworth and H. Hibasami,1981197315320Pegg, A.E.,1986234249262Pochmann, D., B. Rucker, A.M. Battastini and J.J. Sarkis,2004114275281Scaramuzzi, R.J. and D.J. Baker,200326327335Shahbazy, P. and N. Maleknia,20024th Edn.,Slotkin, T.A., D. Persons, R.J. Slepetis, D. Taylor and J. Bartolome,198430211224Xu, H.L., R.A. Santizo, H.M. Koenig and D.A. Pelligrino,2001281H2105H2112Yazawa, T., T. Mizutani, K.Y. Amada, H. Kawata and T. Sekiguchi et al.,200314419201930Zhang, J.G. and W.E. Lindup,19974911361140Berson, S.A. and R.S. Yalow,19731st Edn.,