Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.306.308AhmadiR. OryanSh. 22008112Various clinical observations and experimental data
from in vitro studies suggest that insulin and sex hormones interact.
The main purpose of the present study was to examine the effects of testosterone
and estradiol on serum insulin in rats. Seven week old male and female
albino (Wistar) rats were used in our study. Testosterone enanthate (50
mg kg-1 day-1) or estradiol valerate (200 μ g
kg-1 day-1) were injected intraperiotenally or subcutaneously
in orchidectomised or ovariectomised rats, respectively. In orchidectomised
rats, serum insulin was decreased compared with control animals (p<0.01),
on the other hand, decreasing of serum insulin was prevented by testosterone
replacement (p<0.001). In ovariectomised rats, serum insulin was also
decreased compared with control group (p<0.01) and decreasing of serum
insulin was prevented by estradiol replacement (p<0.05). Conclusively,
present findings indicated that testosterone or estradiol were serum insulin
enhancer hormones in male or female rats, respectively.]]>Buffington, C.K., J.R. Givens and A.E. Kitabchi,19883641A41AChoi, S.B., J.S. Jang and S. Park,200514647864794Diaz-Sanchez, V., S. Morimoto, A. Morales, G. Robles-Diaz and M. Cerbon,199511241245Evans, D.J., R. Murray. and A.H. Kissebah,19847415151525González, C., A. Alonso, N.A. Grueso, F. DÃaz, M.M. Esteban, S. Fernández and A.M. Patterson,2002679931005Haffner, S.M., J. Shaten, M.P. Stern, G.D. Smith and L. Kuller,1996143889897Holmang, A. and P. Bjorntorp,1992144425431Holmäng, A., B.M. Larsson, Z. Brzezinska and P. Bjorntorp,1992262E851E855Kapoor, D., C.J. Malkin, K.S. Channer and T.H. Jones,200563239250Lindheim, S.R., T.A. Buchanan, D.M. Duffy, M.A. Vijod and T. Kojima et al.,19941150154McCarroll, A.M. and K.D. Buchanan,19739174177Morelli, C., C. Garofalo, D. Sisci, S. Del-Rincon and S. Cascio et al.,20042375177526Nagata, C., H. Shimizu, R. Takami, M. Hayashi, N. Takeda and K. Yasuda,200091948953Nielsen, J.H.,1984105245250Pitteloud, N., M. Hardin, A.A. Dwyer, E. Valassi, M. Yialamas, D. Elahi and F.J. Hayes,20059026362641Polderman, K.H., L.J. Gooren, H. Asscheman, A. Bakker and R.J. Heine,199479265271Shoupe, D. and R.A. Lobo,198441385388Stellato, R.K., H.A. Feldman, O. Hamdy, E.S. Horton and J.B. McKinlay,200023490494Sumiko, M., F.M. Cisinta, R.N. Guilermo, M.P. Nestor and D.S. Vicente,200114214421447Waynforth, H.B.,1988pp: 160-163pp: 160-163Yoneda, N., S. Saito, M. Kimura, M. Yamada and M. Iida et al.,199830263265Zhu, M., A. Mizuno, M. Kuwajima, T. Ogino and T. Murakami et al.,199841799805