Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.656.659SelvamA. Panneer GeethaD. 42008114The aim of the present study is to enhance the solubility and
stability of drugs in addition of water-soluble polymer and carbohydrate
complexes. The data show that the polymer polyvinyl alcohol (PVA) interacts
with the free Lamivudine and with the Lamivudine; β-cyclodextrin
(β-CD) inclusion complex, in both cases with particular intermolecular
interaction was studied using ultrasonic technique under different concentrations
at a temperature 303 K. Consequently, the reason of this study was to
improve the biological performance of the drug through enhancing its solubility
and stability. The binary and ternary mixtures prepared inclusion complexes
of Lamivudine in β-CD and PVA. The presence of PVA, changes the drug:
β-CD interaction, a Lamivudine: β-CD: PVA complex was formed.
In addition, the presence of PVA produces a strong increase in the binding
constant at a particular concentration (1.25%). In the ternary complex,
the Lamivudine is wrapped at both ends for the β-CD. In this complex,
the polymer seems to act as a bridge between both β-CD molecules
that bind the Lamivudine.]]>Ganzerli, G., L.V. Santvliet, E. Verschuren and A. Ludwig,199651357362Geetha, D. and C. Rakkappan,200377B525528Geetha, D. and C. Rakkappan,200512199101Geetha, D. and C. Rakkappan,2005121102104Jin, H., R. Esquivel-Sirvent, S.S. Yun and F.B. Stumpe,199598659659Kagathara, V.M., M.R. Sanariya and P.H. Parsania,20003623712374Loftsson, T., H. Fridriksdottir, A.M. Sigurdardottir and H. Ueda,1994110169177Loftsson, T. and M. Brewster,19968510171025Manas Garcia, M.D., F.D. Bardaji, A.H. Albujar and B.P. Alcol,200522485485Ramesh, P.S., D. Geetha and C. Rakkappan,20061266971Siegfried, N.L., P.J. Van Dventer, F.A. Mohomed and G.W. Rutherford,200612CD004535CD004535Sundaresan, B. and A. Srinivasa Rao,19942612861290Sweetman, S.C.,200534th Edn.,pp: 1544pp: 1544Torii, N., K. Hasegawa, M. Ogawa, E. Hashimo and N. Hayashi,2002243434Uekama, K., F. Hirayama and T. Irie,19989820452076