Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.1146.1151Garcinia kola) on Carbon Tetrachloride-Induced Renal Oxidative Damage in Mice]]>AdaramoyeO.A. 1220091216It became evident in this study that carbon tetrachloride (CCl4), can induce renal oxidative damage. The hepatoprotective effects of vitamin E (Vit. E) and kolaviron (KV), a biflavonoid complex from the seeds of Garcinia kola are well documented. The present study was designed to investigate and compare the renal protective effects of Vit. E and KV in mice given CCl4 (1.2 g kg-1) intra-peritoneally thrice a week for two weeks. CCl4 caused a marked increase in serum and renal lipid peroxidation (LPO) by 106 and 225%, respectively. Treatment with KV at 100 and 200 mg kg-1 and Vit. E at 100 mg kg-1 significantly (p<0.05) decreased the CCl4-mediated increase in LPO. Furthermore, CCl4-intoxication decreased the levels of renal reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) by 44, 56 and 43%, respectively. Treatment with KV and Vit. E significantly (p<0.05) ameliorated the GSH and SOD levels. Specifically, KV at 100 and 200 mg kg-1 increased GSH by 32 and 27% and SOD levels by 50 and 53%, respectively. Likewise, treatment with Vit. E increased GSH and SOD levels by 31 and 53%, respectively. Effects on markers of renal functions showed that CCl4-intoxication significantly (p<0.05) elevated serum urea and creatinine by 287 and 186%, respectively. While treatment with Vit. E decreased serum urea and creatinine by 60 and 55%, respectively, KV produced insignificant (p>0.05) effect on these parameters. This study found KV unable to protect against CCl4-induced renal damage but confirmed the potency of Vit. E to enhance recovery from renal oxidative damage.]]>Adaramoye, O.A., V.O. Nwaneri, K.C. Anyanwu, E.O. Farombi and G.O. Emerole,2005Garcinia kola seed extract) in hypercholesterolaemic rats.]]>324046Adaramoye, O.A., E.O. Farombi, E.O. Adeyemi and G.O. Emerole,2005Garcinia Kola seeds.]]>21331339Adaramoye, O.A. and E.O. Adeyemi,2006Garcinia kola seeds.]]>98135141Adaramoye, O.A. and E.O. Adeyemi,2006Garcinia kola in streptozotocin-induced diabetes mellitus rats.]]>58121128Adaramoye, O.A., E.O. Farombi, M. Nssien, S.O. Idowu, O.G. Ademowo and E.O. Adeyemi,2008Garcinia kola seeds in mice intoxicated with carbon tetrachloride.]]>11544550Aebi, H.,19741974pp: 673-684pp: 673-684Aktoz, T., N. Aydogdu, B. Alagol, O. Yalcin, G. Huseyinova and I.H. Atakan,200729535542Arreola-Mendoza, L., J.L. Reyes, E. Melendez, D. Martin, M.C. Namorado, E. Sanchez and L.M. Del-Razo,2006218237246Beştaş, A., M. Kahramanoglu, O.L. Erhan, E. Bolat, I. Ozercan, F. Gursu and F. Gulcu,200830627631Bruning, T., B. Pesch, B. Wiesenhutter, S. Rabstein, M. Lammert, A. Baumuller and H.M. Bolt,200343274285Cotterhill, P.J., F. Scheinmann and T.A. Stenhouse,1978Guttiferae: Kolaflavanone, a new biflavanone from the nuts of Garcinia kola Heckel.]]>1246246Dwivedi, S., R. Sharma, A. Sharma, P. Zimniak, J.D. Ceci, Y.C. Awasthi and P.J. Boor,20064-induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice.]]>2185866El-Daly, E.199693748Farombi, E.O., M.C. Alabi and T.O. Alkuru,2002456368Fumio, F., N. Sachiko, K. Masae, T. Kumiko and K. Takashi,19896175185Gokcimen, A., A. Cim, H.T. Tola, D. Bayram, A. Kocak, F. Ozguner and A. Ayata,200726519525Iwu, M.M., Igboko, O.A., Okunji, C.O. and M.S. Tempesta,1990Garcinia kola.]]>42290292Jaffe, M.,188610391391Jayakumar, T., M. Sakthivel, P.A. Thomas and P. Geraldine,2008176108120Jaramillo-Juarez, F., M.L. Rodriguez-Vazquez, A.R. Rincon-Sanchez, M.M. Consolacion and G.G. Ortiz et al.,20087331338Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275McCay, P.B., E.K. Lai, J.L. Poyer, C.M. DuBose and E.G. Janzen,1984in vivo and in vitro.]]>25921352143McCord, J.M. and I. Fridovich,196924460496055Moron, M.S., J.W. Depierre and B. Mannervik,19795826778Ogeturk, M., I. Kus, A. Kavakli, J. Oner, A. Kukner and M. Sarsilmaz,2005238592Randle, L.E., C.E. Goldring, C.A. Benson, P.N. Metcalfe, N.R. Kitteringham, B.K. Park and D.P. Williams,2008243249260Shi, Z.M., P. Feng, D.Q. Jiang and X.J. Wang,20061240524055Soni, B., N.P. Visavadiya and D. Madamwar,20084-induced toxicity in rats.]]>2485965Talke, H. and G.E. Schubert,19651174175, (In German)Terashima, K., Y. Takaya and M. Niwa, 2002Garcinia kola.]]>1016191625Tietz, N.W.,19763rd Edn.,pp: 993-997pp: 993-997Tirkey, N., S. Pilkhwal, A. Kuhad and K. Chopra,200551515Tung, Y.T., J.H. Wu, C.C. Huang, H.C. Peng, Y.L. Chen, S.C. Yang and S.T. Chang,20094713851392Walls, R., K.S. Kumar and P. Hochstein,1976100119128