Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.383.387OloyedeA. OkpuzorJ. OmidijiO. 42009124The cytological and toxicological potentials of an ethanol extract of a decoction used in South Western Nigeria for the management of breast tumors were evaluated using mice and Allium cepa models. The oral administration of the extract to the mice within the range of 400-1600 mg kg-1 b. wt., dosage did not result in any mortality until 2000 mg kg-1 body weight (b. wt.), when 60% mortality occurred. The LD50 of the extract administered intraperitoneally, was 400 mg kg-1 b. wt. Furthermore, the extract induced macroscopic and microscopic changes causing a dose-related root growth inhibition and chromosomal aberrations in Allium cepa. The effect of the extract was more pronounced at 1600 mg kg-1,dose while the EC50 was at 380 mg after 72 h. This decoction may present cytological and toxicological potential for managing breast tumors and corroborates its use in ethno medicine.]]>Badria, F.A.R., W.E. Houssein, M.G. Zaghloul and A.F. Halim,200139120126Bishayee, A. and M. Chatterjee,1994Mikania cordata root extract against physical and chemical factors-induced gastric erosions in experimental animals.]]>60110113Etuk, E.U., B.M. Agaie, P.A. Onyeyili and C.U. Ottah,2006Boswellia dalzielii in albino rats.]]>38359360Fiskesjo, G.,1988Allium test-an alternative in environmental studies: The relative toxicity of metal ions.]]>197243260Gathumbi, P.K., J.W Mwangi, G.M. Mugera and S.M. Njiro,2002Prunus africana stem bark on rats: Gross and histological lesions.]]>16244247Lewis, J.K.,2006pp: 312pp: 312Li, S., C.E. Oakley, G. Chen, X. Han, B.R. Oakley and X. Xiang,20051635913605Nwanjo, H.U.,2005Vernonia amygdalina on plasma lipoprotein and oxidative status in diabetic rat models.]]>203942Odeigah, P.G., J. Ijimakinwa, B. Lawal and R. Oyeniyi,1997Allium test.]]>25311321Odugbemi, T.,20061st Edn.,Pages: 283Pages: 283Okochi, V.I., J. Okpuzor and L.A. Alli,20032237240Oloyede, A.M., J. Okpuzor, O. Omidiji and H.O.C. Mbagwu,20084196201Rang, H.P., M. Dale and J. Ritter,20014th Edn.,Rank, J.,2003Allium anaphase-telophase chromosome aberration assay.]]>13842Rathore, H.S., K. Amit, S. Anjiali, S. Sharad and D. Bhatnagar,2006Terminalia chebula) in Allium tests.]]>109297Sehgal, R., S. Roy and V.L. Kumar,2006Calotropis procera and Podophyllotoxin in Allium cepa root model.]]>30913Zhu, M., K.T. Lew and P. Leung,200216276280