Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.98.100NaghshvarF. TorabizadehZh. EmadianO. EnamiK. GhahremaniM. 12009121This study want to determine correlation of cyclooxygenans
2 (Cox-2) expression and inflammatory reaction in colorectal carcinoma.
Archival H and E slides of 150 patients with primary colorectal carcinoma
were reviewed to confirm pathological feature and to select suitable tissue
blocks for immunohistochemical staining with mouse monoclonal antibody
against human Cox-2 and various inflammatory cells. After scoring, statistical
analysis were carried out with SPSS software, χ2 methods
and bivariate pearson correlation analysis. The expression of Cox-2 (grade
3 to 7) in 71.3% of patients associated with mast cells, neutrophils,
eosinophils, macrophages, CD3+ lymphocytes infiltration was
significant (p = 0.001). Correlation of Cox-2 expression associated with
CD8+ lymphocytes infiltration was not significant (p = 0.569).
Also CD3+ lymphocytes show severe infliltration when the expression
of Cox-2 is negative (p<0.05). The main purpose of this study was to
evaluate the interaction between the Cox-2 expression and inflammatory
cells infiltration. This study showed that there is a close relationship
of Cox-2 expression and mast cells, neutrophils, eosinophils, macrophages
and CD3+ lymphocytes. The only exception was CD8+
lymphocytes. It is may be due to independent role of anti tumoral effect
of this inflammatory cells.]]>Williams, C.S., M. Mann and R.N. DuBois,19991879087916Gao, J., G. Arbman, T. Wadhara, H. Zhang and X.F. Sun,20051121792183Hla, T. and K. Neilson,19928973847388Klintrup, K., J.M. Mäkinen, S. Kauppila, P.O. Väre and J. Melkko et al.,20054126452654Masfercer, J.L., K.M. Leahy, A.T. Koki, B.S. Zweifel, S.L. Settle and B.M. Woerner et al.,20006013061311Nagtegaal, I.D., C.A. Marijnen, E.K. Kranenbarg, A. Mulder-Stapel and J. Hermans et al.,2001114712407Soumaoro, T.L., H. Vetake, T. Higvchi, Y. Takag, M. Enomoto and K. Sugihara,20041084658471Statton, M.S. and D.S. Alberts,2002163751Rosai, J.,20049th Edn.,pp: 819pp: 819Yao, H.B., A.G. Wu, Y.J. Chen and B.H. Tang,20052515241528Zhang, H. and X.F. Sun,20029710371041